CAP1 Inhibitors

The chemical class of CAP1 Inhibitors encompasses a range of compounds that indirectly influence the function of CAP1 by targeting various aspects of actin filament dynamics and related signaling pathways. These inhibitors do not directly target CAP1 but affect its function by altering the actin cytoskeleton, which is central to CAP1's role.

In this class, compounds like Latrunculin A, Cytochalasin D, Jasplakinolide, Swinholide A, and Phalloidin directly target actin filaments by either destabilizing or stabilizing them. This directly contrasts with CAP1's role in regulating actin filament turnover, thereby indirectly inhibiting its function. Further, inhibitors that target actin-myosin interactions or actin polymerization dynamics, such as ML-7, Y-27632, Blebbistatin, CK-666, SMIFH2, Wiskostatin, and Tropomyosin, represent a broader approach. By modulating the dynamics of actin filaments and related proteins, these compounds can indirectly impact CAP1's function in cytoskeletal rearrangements.