CaMKIIγ Activators
The chemical class known as CaMKIIγ activators encompasses a diverse array of compounds that exert their influence on the activation of CaMKIIγ through intricate cellular signaling mechanisms. One prominent group within this class includes compounds such as A769662, which directly activate AMP-activated protein kinase (AMPK). The activation of AMPK triggers downstream signaling events that intersect with CaMKIIγ-regulated pathways, creating a cascade effect that culminates in the phosphorylation and activation of CaMKIIγ. This direct activation pathway emphasizes the importance of AMPK in the regulation of CaMKIIγ activity and highlights the interconnectedness of cellular signaling networks. Another subset of CaMKIIγ activators includes compounds like NS309, a selective activator of small conductance Ca2+-activated K+ channels (SK channels). Activation of SK channels induces membrane hyperpolarization and reduces intracellular Ca2+ levels, leading to the indirect modulation of CaMKIIγ activation. The crosstalk between ion channel signaling and CaMKIIγ-regulated pathways exemplifies the intricate interplay between cellular membrane dynamics and protein activation. Similarly, compounds like Bay K 8644, a calcium channel activator, directly enhance L-type calcium channel currents, influencing intracellular Ca2+ concentrations and impacting CaMKIIγ activation through calcium-dependent signaling pathways.
Raloxifene, a selective estrogen receptor modulator (SERM), represents another facet of CaMKIIγ activators. Through estrogen receptor-mediated pathways, raloxifene triggers downstream signaling events that intersect with CaMKIIγ-regulated pathways, showcasing the complex interplay between nuclear receptor signaling and the activation of CaMKIIγ. This diversity within the chemical class highlights the multifaceted nature of CaMKIIγ activation, with each compound exerting its effects through distinct cellular signaling mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662 is a potent and selective activator of AMP-activated protein kinase (AMPK). By directly activating AMPK, it triggers downstream signaling cascades, including inhibition of mTOR and induction of autophagy. This, in turn, indirectly influences CaMKIIγ activation through the crosstalk between AMPK and CaMKIIγ-regulated pathways within the cellular context. | ||||||
NS309 | 18711-16-5 | sc-253202 | 5 mg | $108.00 | ||
NS309 is a selective and potent activator of small conductance Ca2+-activated K+ channels (SK channels). Activation of SK channels leads to membrane hyperpolarization and reduced intracellular Ca2+ levels, indirectly influencing CaMKIIγ activation. The decreased Ca2+ availability modulates CaMKIIγ activity through the interplay of Ca2+ signaling pathways within the cellular milieu. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP levels activate protein kinase A (PKA), which, in turn, modulates CaMKIIγ activity. This indirect activation occurs through the integration of cAMP/PKA signaling pathways, resulting in a cascade effect that ultimately influences CaMKIIγ phosphorylation and activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog. Its presence in cells leads to the activation of PKA, a key player in cellular signaling. By influencing PKA-dependent pathways, dibutyryl cAMP indirectly modulates CaMKIIγ activation, showcasing the intricate interplay between cAMP/PKA signaling and the regulation of CaMKIIγ within the cellular context. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644 is a calcium channel activator that specifically enhances L-type calcium channel currents. This direct modulation of calcium channels influences intracellular Ca2+ concentrations, subsequently impacting CaMKIIγ activation. The mechanism involves the direct interaction of calcium influx through L-type channels and the activation of CaMKIIγ-regulated pathways. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Raloxifene, a selective estrogen receptor modulator (SERM), influences CaMKIIγ activation through estrogen receptor-mediated pathways. Estrogen receptor activation by raloxifene triggers downstream signaling events that intersect with CaMKIIγ-regulated pathways, showcasing the complexity of nuclear receptor signaling in modulating intracellular protein activity. | ||||||
Tolfenamic Acid | 13710-19-5 | sc-204918 sc-204918A | 5 g 25 g | $69.00 $312.00 | ||
Tolfenamic acid is an anti-inflammatory agent that can indirectly influence CaMKIIγ activation. It exerts its effects through modulation of arachidonic acid metabolism, leading to altered prostaglandin production. The resulting changes in cellular signaling, particularly those involving prostaglandins, contribute to the indirect modulation of CaMKIIγ activity within the cellular context. | ||||||
Nicorandil | 65141-46-0 | sc-200995 sc-200995B sc-200995A sc-200995C | 50 mg 100 mg 250 mg 1 g | $57.00 $98.00 $240.00 $500.00 | 4 | |
Nicorandil is a hybrid compound with both nitrate-like and ATP-sensitive potassium (KATP) channel-opening properties. By activating KATP channels, nicorandil induces membrane hyperpolarization and modulates cellular redox status. These changes contribute to the indirect activation of CaMKIIγ, highlighting the intricate interplay between membrane potential, redox signaling, and CaMKIIγ activity. | ||||||
Levosimendan | 141505-33-1 | sc-204792 sc-204792A | 100 mg 250 mg | $102.00 $224.00 | ||
Levosimendan is a calcium sensitizer and potassium channel opener. Its positive inotropic effects are mediated by increased calcium sensitivity of cardiac myofilaments. The ensuing modulation of intracellular calcium dynamics indirectly influences CaMKIIγ activation, emphasizing the interconnection between contractile machinery, calcium homeostasis, and the regulation of CaMKIIγ within cardiomyocytes. | ||||||
GSK1016790A | 942206-85-1 | sc-255193 | 10 mg | $260.00 | 6 | |
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel activator. Activation of TRPV4 channels leads to calcium influx, influencing intracellular calcium levels. This, in turn, affects CaMKIIγ activation through the intricate interplay between TRPV4-mediated calcium signaling and CaMKIIγ-regulated pathways within the cellular milieu. | ||||||