Calponin 2 Inhibitors
Calponin 2 inhibitors encompass a diverse array of chemicals designed to modulate the activity of this pivotal protein involved in the regulation of actomyosin contractility and cellular motility. These inhibitors can be categorized into direct inhibitors, which target Calponin 2 itself, and indirect inhibitors, which influence its activity through modulation of upstream or downstream signaling pathways. Direct inhibitors, such as ML-7 and Blebbistatin, act specifically on Calponin 2 or its interacting partners to interfere with the regulation of actomyosin dynamics. ML-7 inhibits myosin light chain kinase (MLCK), a key regulator of Calponin 2 phosphorylation, leading to the modulation of smooth muscle contraction. Blebbistatin, on the other hand, directly inhibits myosin II, disrupting the force generation required for actin-myosin interactions and impacting Calponin 2's regulatory role. Indirect inhibitors, including Y-27632 and H-89, target upstream signaling molecules, such as Rho-associated protein kinase (ROCK) and protein kinase A (PKA), influencing Calponin 2 activity through a cascade of events. Y-27632's inhibition of ROCK disrupts the signaling pathways leading to Calponin 2 activation, while H-89 interferes with PKA-dependent phosphorylation events regulating Calponin 2 function.
Chemicals like Jasplakinolide and Cytochalasin D indirectly modulate Calponin 2 by altering actin dynamics. Jasplakinolide stabilizes F-actin, influencing Calponin 2's interaction with actin filaments. Cytochalasin D, on the other hand, disrupts actin polymerization, indirectly impacting Calponin 2's ability to regulate actomyosin contractility. The inhibitors CK-666, CK-869, and CK-548 target the Arp2/3 complex involved in actin polymerization, offering indirect modulation of Calponin 2 by affecting actin cytoskeleton dynamics. Calyculin A, a phosphatase inhibitor, indirectly influences Calponin 2 by sustaining its phosphorylated state, providing a tool for investigating phosphorylation-dependent mechanisms governing Calponin 2 function. In summary, these diverse inhibitors provide valuable tools for researchers to dissect the intricate regulatory networks controlling Calponin 2 activity and its pivotal role in cellular processes such as smooth muscle contraction and cellular motility.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is a direct inhibitor of Calponin 2 that acts by suppressing myosin light chain kinase (MLCK). By inhibiting MLCK, ML-7 disrupts the phosphorylation of myosin light chain, a crucial step in actin-myosin interactions. This disruption leads to a decrease in Calponin 2 phosphorylation, thereby modulating its ability to regulate actomyosin contractility. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), an upstream regulator of Calponin 2. By inhibiting ROCK, Y-27632 interferes with the downstream signaling cascades that lead to Calponin 2 activation. This indirect modulation alters Calponin 2's ability to interact with actin and modulate smooth muscle contraction. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is an indirect inhibitor of Calponin 2 that influences actin dynamics. By stabilizing F-actin, jasplakinolide alters the availability of actin filaments for Calponin 2 binding. This indirect modulation impacts Calponin 2's ability to regulate actomyosin contractility. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is a chemical inhibitor that indirectly influences Calponin 2 by targeting Wiskott-Aldrich syndrome protein (WASP). By inhibiting WASP, Wiskostatin disrupts the actin polymerization machinery, altering the cytoskeletal architecture and, consequently, the regulation of Calponin 2. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an indirect inhibitor of Calponin 2 that disrupts actin polymerization by binding to the fast-growing ends of actin filaments. By influencing actin dynamics, cytochalasin D indirectly modulates Calponin 2's ability to interact with actin and regulate smooth muscle contraction. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is a direct inhibitor of myosin II, an interacting partner of Calponin 2 in the regulation of actomyosin contractility. By specifically inhibiting myosin II ATPase activity, blebbistatin disrupts the force generation required for actin-myosin interactions. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H1152 is a selective inhibitor of Rho kinase, an upstream regulator of Calponin 2. By inhibiting Rho kinase, H1152 interferes with the signaling pathways that lead to Calponin 2 activation. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is a chemical inhibitor that indirectly modulates Calponin 2 by targeting the Arp2/3 complex involved in actin polymerization. By inhibiting the Arp2/3 complex, CK-666 disrupts the branching of actin filaments, altering the availability of actin for Calponin 2 binding. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent phosphatase inhibitor that indirectly influences Calponin 2 by preventing the dephosphorylation of its regulatory sites. By inhibiting phosphatases, Calyculin A sustains the phosphorylated state of Calponin 2, modulating its ability to regulate actomyosin contractility. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 is a chemical inhibitor that indirectly modulates Calponin 2 by targeting the Arp2/3 complex involved in actin polymerization. By inhibiting the Arp2/3 complex, CK-869 disrupts the branching of actin filaments, altering the availability of actin for Calponin 2 binding. | ||||||