Calpain 6 Activators

Calpain 6 (CAPN6), a member of the calpain family of proteins, is encoded by the CAPN6 gene in humans. Calpains are a group of calcium-dependent cysteine proteases involved in various cellular processes, including cytoskeletal remodeling, signal transduction, and apoptosis.Unlike other members of the calpain family, Calpain 6 lacks the conventional catalytic triad necessary for protease activity. This suggests that it may function differently from typical calpains, which are known for their enzymatic roles in cleaving and activating other proteins. Calpain 6 is predominantly expressed in embryonic tissues and seems to play a critical role in embryonic development. It's particularly involved in cell migration and cytoskeleton organization during the development process.Studies have suggested that Calpain 6 is implicated in the regulation of microtubule stability. Microtubules are a component of the cell's cytoskeleton and are crucial for cell shape, division, and intracellular transport. By influencing microtubule dynamics, Calpain 6 can significantly impact cellular function and development.While the exact role of Calpain 6 in disease is not fully understood, its expression has been associated with several types of cancer. For instance, its overexpression has been observed in ovarian cancer and is thought to contribute to disease progression.