Date published: 2026-3-3

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Calpain 13 Activators

Calpain 13 Activators, as a class, would encompass compounds that can indirectly lead to the activation of Calpain 13, primarily by modulating intracellular calcium levels. These activators can function through various mechanisms: some disrupt the calcium sequestration into the endoplasmic reticulum (ER) by inhibiting the SERCA pump, as seen with Thapsigargin and Cyclopiazonic acid, leading to an increase in cytosolic calcium that can enhance the proteolytic activity of Calpain 13. Others, like A23187 and Ryanodine, act directly on calcium channels or receptors to facilitate the release of calcium from intracellular stores, increasing the local concentration of calcium necessary for theCalpain 13 activation, and therefore enhancing Calpain 13's functional activity. Compounds such as 4-Chloro-m-cresol and Caffeine induce calcium release through ryanodine receptor channels, which play a pivotal role in the regulation of intracellular calcium. These compounds ensure that the intracellular milieu is rich in calcium ions, which is a requisite for Calpain 13 activation. Carbachol, by acting as a cholinergic agonist, increases intracellular calcium by mobilizing calcium from the ER, thereby providing an environment conducive to Calpain 13 activation. The functional activity of Calpain 13 is further influenced by compounds that modulate the cellular calcium channels. For instance, calcium channel blockers like Verapamil and Nicardipine can indirectly lead to an increase in intracellular calcium through homeostatic mechanisms that attempt to maintain calcium balance, possibly resulting in the upregulation of Calpain 13 activity.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

A SERCA pump inhibitor that leads to increased intracellular calcium levels. As Calpain 13 requires calcium for activation, the elevation of intracellular calcium by Thapsigargin can enhance Calpain 13 activity by providing the necessary ions for its catalytic activity.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$55.00
$131.00
$203.00
$317.00
23
(1)

Calcium ionophore that increases intracellular calcium by facilitating the influx of extracellular calcium. This increase in intracellular calcium concentration can enhance the activity of Calpain 13 by providing the calcium ions needed for its enzymatic function.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
50 g
100 g
250 g
1 kg
5 kg
$33.00
$67.00
$97.00
$192.00
$775.00
13
(1)

A known stimulator of calcium release from intracellular stores. It can enhance Calpain 13 activity by increasing cytosolic calcium concentration, thereby indirectly contributing to the activation state of Calpain 13.

Carbachol

51-83-2sc-202092
sc-202092A
sc-202092C
sc-202092D
sc-202092B
sc-202092E
1 g
10 g
25 g
50 g
100 g
250 g
$122.00
$281.00
$388.00
$683.00
$1428.00
$3060.00
12
(2)

A cholinergic agonist that can cause the release of calcium from intracellular stores, thereby potentially enhancing the activation of Calpain 13 by increasing the intracellular calcium levels.

Ryanodine

15662-33-6sc-201523
sc-201523A
1 mg
5 mg
$223.00
$799.00
19
(2)

Targets ryanodine receptors to induce release of calcium from the sarcoplasmic and endoplasmic reticulum. By increasing intracellular calcium, Ryanodine can indirectly enhance the activity of Calpain 13.

Cyclopiazonic Acid

18172-33-3sc-201510
sc-201510A
10 mg
50 mg
$176.00
$624.00
3
(1)

An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium levels. Elevated calcium can enhance Calpain 13 activity as calpains are calcium-dependent proteases.

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

A calcium channel blocker that can lead to the activation of compensatory mechanisms to increase intracellular calcium, potentially enhancing Calpain 13 activity by indirectly increasing the level of calcium ions available for Calpain 13 activation.

Nicardipine hydrochloride

54527-84-3sc-202731
sc-202731A
1 g
5 g
$33.00
$83.00
5
(2)

Another calcium channel blocker that may trigger homeostatic responses resulting in increased intracellular calcium, which can enhance the activity of Calpain 13 by providing more calcium ions necessary for its activation.

FPL-64176

120934-96-5sc-201491
5 mg
$83.00
1
(1)

A calcium channel activator that can increase intracellular calcium concentration, indirectly enhancing Calpain 13 activity by increasing the availability of calcium ions.

(±)-Bay K 8644

71145-03-4sc-203324
sc-203324A
sc-203324B
1 mg
5 mg
50 mg
$84.00
$196.00
$817.00
(0)

An L-type calcium channel agonist that can increase intracellular calcium, thereby potentially enhancing the functional activity of Calpain 13 through increased availability of calcium ions for its activation.