CALHM2 Inhibitors
vCALHM2 inhibitors belong to a diverse group of chemicals that affect the cellular calcium homeostasis and signaling pathways. These chemicals are not inhibitors of CALHM2 in the direct sense but interact with various components of the cellular signaling machinery that may impact the function of CALHM2. The mechanisms of action of these chemicals include blockade of voltage-gated calcium channels (e.g., Verapamil, Nifedipine, Diltiazem), modulation of intracellular calcium release (e.g., Thapsigargin, Xestospongin C, Ryanodine), and alteration of calcium channel activity at a more general level (e.g., 2-APB, Ruthenium Red). Some of these compounds, like Carbenoxolone, also influence ionic currents and gap junction communication, thereby affecting the cellular ionic environment and potentially the activity of CALHM2.
These inhibitors are typically characterized by their ability to modulate calcium-dependent physiological processes and are employed in research to dissect the intricacies of calcium signaling pathways. For instance, Verapamil and Diltiazem are known for their selectivity in blocking L-type calcium channels, which are crucial for the regulation of muscle contraction andneurotransmitter release. Gadolinium chloride and Ruthenium Red are known to be broad-spectrum inhibitors of ion channels, including those permeable to calcium, thus potentially influencing the ion homeostasis that CALHM2 is believed to regulate. Chemicals like SKF-96365 and 2-APB interfere with receptor-mediated calcium entry and store-operated calcium entry, respectively, both of which are important mechanisms in the regulation of intracellular calcium levels.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that regulates the influx of calcium ions through voltage-gated calcium channels, thereby indirectly affecting the calcium homeostasis that CALHM2 is posited to be involved in. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB modulates the activity of several types of ion channels, including those that regulate intracellular calcium levels. Its effect on these channels can influence the calcium signaling pathways that CALHM2 may participate in. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is another calcium channel blocker, similar to Verapamil, that alters calcium ion entry into cells and could indirectly modulate CALHM2-related signaling by altering calcium dynamics. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, also a calcium channel blocker, can affect calcium ion conductance and thus influence CALHM2's potential role in calcium homeostasis. | ||||||
Carbenoxolone | 5697-56-3 | sc-507294 | 1 g | $50.00 | ||
Carbenoxolone inhibits gap junction communication and could affect cellular ionic environments, possibly influencing CALHM2 activity indirectly through alterations in intracellular signaling. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is an inhibitor of several types of calcium channels and might therefore alter the calcium signaling pathways with which CALHM2 is associated. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 is an inhibitor of receptor-mediated calcium entry and store-operated channels, potentially impacting signaling pathways relevant to CALHM2 function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that disrupts calcium homeostasis within cells, which could indirectly influence CALHM2 activity by altering calcium signaling. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine selectively binds to ryanodine receptors and modulates calcium release from the sarcoplasmic/endoplasmic reticulum, which may indirectly influence CALHM2 through intracellular calcium signaling. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine is a local anesthetic that blocks voltage-gated sodium channels, but it also can affect calcium signaling pathways, which could in turn impact CALHM2 function. | ||||||