CagA Activators
CagA activators represent a distinctive class of chemical compounds specifically engineered to modulate the activity of CagA, a virulence factor associated with the bacterium Helicobacter pylori. Helicobacter pylori is a pathogenic bacterium that colonizes the human stomach and is implicated in the development of various gastric disorders, including peptic ulcers and gastritis. CagA (Cytotoxin-associated gene A) is a protein that is injected into the host's gastric epithelial cells by the bacterium's type IV secretion system. Once inside the host cell, CagA can interact with various host cell proteins and affect numerous signaling pathways. The exact mechanisms through which CagA contributes to H. pylori pathogenesis are complex and multifaceted, involving its ability to deregulate cell signaling, disrupt cellular junctions, and promote chronic inflammation.
CagA activators are synthesized to interact with CagA and influence its activity within host cells. These compounds are essential tools for researchers aiming to decipher the intricate molecular mechanisms underpinning H. pylori-induced gastric diseases. By manipulating CagA's activity, scientists can gain insights into how this virulence factor contributes to the pathogenicity of H. pylori and the associated cellular responses. Understanding the actions of CagA activators is instrumental in unraveling the host-pathogen interactions that occur during H. pylori infection, shedding light on the complex interplay between bacterial virulence factors and host cell signaling pathways within the context of gastric disorders.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
High concentrations of sodium chloride have been shown to enhance the expression of CagA by affecting the cellular osmotic balance and potentially altering bacterial gene expression. | ||||||
Metronidazole | 443-48-1 | sc-204805 sc-204805A | 5 g 25 g | $84.00 $205.00 | 11 | |
As an antimicrobial agent, metronidazole can create selective pressure on H. pylori, possibly leading to upregulation of CagA expression as a bacterial response mechanism. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin may affect CagA expression indirectly through its impact on gastric mucosal integrity and subsequent changes in the bacterial microenvironment. | ||||||
Clarithromycin | 81103-11-9 | sc-205634 sc-205634A | 100 mg 250 mg | $77.00 $122.00 | 1 | |
This compound, while targeting H. pylori, may induce stress responses in the bacterium that include altered CagA expression. | ||||||
Amoxicillin | 26787-78-0 | sc-485485 | 5 g | $179.00 | 3 | |
Amoxicillin can exert selective pressure on H. pylori, potentially affecting CagA expression. | ||||||
Sucrose | 57-50-1 | sc-204311 sc-204311B sc-204311C sc-204311A | 0.5 kg 50 kg 100 kg 5 kg | $58.00 $2000.00 $3500.00 $250.00 | 6 | |
Sucrose, as a dietary sugar, can modulate the gastric environment, potentially influencing H. pylori gene expression including CagA. | ||||||
Iron(III) chloride | 7705-08-0 | sc-215192 sc-215192A sc-215192B | 10 g 100 g 500 g | $41.00 $46.00 $87.00 | ||
Iron availability can affect bacterial growth and gene expression, potentially influencing CagA expression in iron-rich environments. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
As a proton pump inhibitor, omeprazole alters gastric acidity, which can influence H. pylori colonization and potentially CagA expression. | ||||||
Levofloxacin | 100986-85-4 | sc-252953 sc-252953B sc-252953A | 10 mg 250 mg 1 g | $40.00 $46.00 $54.00 | 3 | |
This compound can exert selective pressure on H. pylori, potentially leading to changes in gene expression including CagA. | ||||||