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Metronidazole (CAS 443-48-1)

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Alternate Names:
Metronidazole is also known as 2-Methyl-5-nitroimidazole-1-ethanol.
Application:
Metronidazole is an antibiotic affective against protozoa and anaerobic gram-positive and gram-negative bacteria.
CAS Number:
443-48-1
Purity:
≥99%
Molecular Weight:
171.15
Molecular Formula:
C6H9N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Metronidazole is a limited spectrum antibiotic that actively deters the growth of protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria. The first use of Metronidazole was to suppress protozoans such as Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Further studies show that Metronidazole has been used to repress the growth of gram-negative anaerobes belonging to the Bacteroides and Fusobacterium, and gram-positive anaerobes such as peptostreptococcus and Clostridia. The advantages of this antiobiotic is that Metronidazole affects a high percentage of gram-negative bacteria and has greater tissue penetration. Furthermore, the gene hefA codes for the TolC efflux pump in Helicobacter pylori, which is resistant to Metronidazole.


Metronidazole (CAS 443-48-1) References

  1. [Metronidazole].  |  Martinez, V. and Caumes, E. 2001. Ann Dermatol Venereol. 128: 903-9. PMID: 11590342
  2. [Tetracyclines, sulfonamides, and metronidazole].  |  Vicente, D. and Pérez-Trallero, E. 2010. Enferm Infecc Microbiol Clin. 28: 122-30. PMID: 20097452
  3. Enhanced bacterial efflux system is the first step to the development of metronidazole resistance in Helicobacter pylori.  |  Tsugawa, H., et al. 2011. Biochem Biophys Res Commun. 404: 656-60. PMID: 21147064
  4. [Controlling wound odor with metronidazole: a systematic review].  |  Castro, DL. and Santos, VL. 2015. Rev Esc Enferm USP. 49: 858-63. PMID: 26516758
  5. Low efficacy of metronidazole in the eradication of Blastocystis hominis in symptomatic patients: Case series and systematic literature review.  |  Batista, L., et al. 2017. Gastroenterol Hepatol. 40: 381-387. PMID: 28279442
  6. Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms.  |  Dingsdag, SA. and Hunter, N. 2018. J Antimicrob Chemother. 73: 265-279. PMID: 29077920
  7. Metronidazole stewardship initiative at Christchurch hospitals-achievable with immediate benefits.  |  Gardiner, SJ., et al. 2018. N Z Med J. 131: 53-58. PMID: 29649197
  8. Symposium on antimicrobial agents. Metronidazole.  |  Rosenblatt, JE. and Edson, RS. 1987. Mayo Clin Proc. 62: 1013-7. PMID: 3312851
  9. Effects of metronidazole on mesophilic and thermophilic fermentation: Biodegradation mechanisms, microbial communities, and reversibility.  |  Zhao, W., et al. 2022. Bioresour Technol. 362: 127795. PMID: 35988858
  10. Metronidazole in anaerobic infections: a review of its activity, pharmacokinetics and therapeutic use.  |  Brogden, RN., et al. 1978. Drugs. 16: 387-417. PMID: 363399
  11. Genotoxicity and carcinogenicity of metronidazole.  |  Dobiás, L., et al. 1994. Mutat Res. 317: 177-94. PMID: 7515153
  12. Flagyl (metronidazole hydrochloride).  |  Claussen, DW. 1993. Gastroenterol Nurs. 15: 178-80. PMID: 8443266
  13. Metronidazole. A therapeutic review and update.  |  Freeman, CD., et al. 1997. Drugs. 54: 679-708. PMID: 9360057

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Metronidazole, 5 g

sc-204805
5 g
$84.00

Metronidazole, 25 g

sc-204805A
25 g
$205.00