Cacna2d3 Inhibitors
Chemical inhibitors of Cacna2d3 include a variety of compounds that act on different types of calcium channels, which are crucial for the function of this protein. Gabapentin and Pregabalin, for instance, bind directly to the α2δ subunit of voltage-gated calcium channels, to which Cacna2d3 belongs. This binding inhibits the influx of calcium ions through these channels, leading to a decrease in the release of neurotransmitters. Their actions are highly specific to the α2δ subunit and result in an inhibition of the channel's overall activity, thereby functionally inhibiting the protein. Further, Mibefradil and Ethosuximide selectively block T-type calcium channels. Though these channels are not the primary type associated with Cacna2d3, the blockade can still reduce the overall activity of calcium channels in cells where Cacna2d3 is expressed, leading to an indirect inhibition of its function. This is due to the fact that calcium channel subtypes can interact and regulate each other's activity, meaning that inhibition of one subtype can influence the activity of another.
Moreover, L-type calcium channel blockers such as Nifedipine, Verapamil, Diltiazem, Amlodipine, Isradipine, Felodipine, and Lacidipine can indirectly influence Cacna2d3 activity. These chemicals inhibit calcium influx through L-type channels, which can alter the calcium dynamics and regulatory mechanisms in cells that express Cacna2d3. The precise action of these drugs leads to a reduced calcium current, which in turn can functionally inhibit the contribution of Cacna2d3 to the channel complex. Zonisamide also inhibits T-type calcium channels, and by doing so, it can decrease the conductance of calcium ions through channels involving Cacna2d3, thereby reducing its functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $52.00 $92.00 $132.00 | 7 | |
Gabapentin binds to the α2δ subunit of voltage-gated calcium channels like Cacna2d3, inhibiting calcium influx and attenuating neurotransmitter release. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
Mibefradil blocks T-type calcium channels, which may functionally inhibit Cacna2d3 by reducing the overall calcium influx in cells expressing this subunit, thereby inhibiting the channel's function. | ||||||
Ethosuximide | 77-67-8 | sc-211431 | 1 g | $300.00 | ||
Ethosuximide is a T-type calcium channel blocker that can inhibit channels associated with Cacna2d3 by decreasing the entry of calcium into neurons, potentially diminishing the activity of channels involving this protein. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that preferentially inhibits L-type channels but may exert functional inhibition on Cacna2d3-containing channels by altering the overall calcium balance and channel regulation in cells where Cacna2d3 is present. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, an L-type calcium channel antagonist, can potentially inhibit the function of Cacna2d3 by modulating the calcium channel activity in cells expressing this subunit, leading to reduced calcium influx. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem inhibits L-type calcium channels and might indirectly inhibit Cacna2d3 function by decreasing the calcium entry through the channels where this protein is a component, thus diminishing its functional contribution to neuronal excitability. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine is an inhibitor of L-type calcium channels and can lead to functional inhibition of Cacna2d3 by altering the dynamics of calcium entry in cells where this protein contributes to the formation of calcium channels. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $86.00 $318.00 | 1 | |
Isradipine selectively blocks L-type calcium channels, which may indirectly inhibit Cacna2d3 activity by reducing calcium ion conductance through channels that contain this subunit, thus inhibiting its role in neurotransmission. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $89.00 $218.00 | 1 | |
Felodipine acts on L-type calcium channels, which may lead to a functional inhibition of Cacna2d3 by reducing the influx of calcium through channels involving this protein, therefore inhibiting its activity. | ||||||
trans Lacidipine | 103890-78-4 | sc-213066 | 10 mg | $153.00 | ||
Lacidipine is a calcium channel blocker that preferentially inhibits L-type channels but could also functionally inhibit the activity of Cacna2d3 by decreasing the availability of calcium ions for channels where Cacna2d3 is a part, thereby reducing the physiological response mediated by these channels, such as neurotransmitter release or muscle contraction. | ||||||