Cables2 Activators

Cdk5 and Abl enzyme substrate 2 (Cables2) is a protein in humans encoded by the CABLES2 gene. It is a member of the Cables family of proteins, which are characterized by their ability to mediate interactions between serine/threonine and tyrosine kinases. Cables2 plays a critical role in cell cycle regulation, influencing the transition between different phases of cell division.The protein Cables2 is known to interact with cyclin-dependent kinases (Cdks), including Cdk1 and Cdk2, which are key regulators of the cell cycle that drive the progression through various checkpoints. These interactions are crucial for ensuring the proper timing of cell cycle events and maintaining genomic stability. Cables2 acts as a link, integrating signals that dictate cell proliferation, differentiation, and apoptosis.

In the context of development and differentiation, Cables2 has been implicated in influencing the balance between cellular growth and differentiation. Its role in the nervous system has garnered attention, particularly with regard to its interactions with Cdk5, a kinase known for its importance in neuronal development and function.Furthermore, Cables2 is also of interest in oncology research due to its potential tumor suppressor function. Loss of Cables2 expression has been observed in various types of cancers, and it is hypothesized that this loss may contribute to the uncontrolled cell proliferation characteristic of tumorigenesis. The mechanisms by which Cables2 suppresses tumor formation might involve the modulation of Cdk activity, thereby affecting cell cycle progression and preventing aberrant cell division.