CA IX Activators
Common CA IX Activators include, but are not limited to Cobalt(II) chloride CAS 7646-79-9, Dimethyloxaloylglycine (DMOG) CAS 89464-63-1, Acriflavine CAS 8048-52-0, YC-1 CAS 170632-47-0 and Cadmium chloride, anhydrous CAS 10108-64-2.
Carbonic anhydrase IX (CA IX) activators are compounds that enhance the activity or stimulate the expression of CA IX, an enzyme belonging to the carbonic anhydrase family. Carbonic anhydrases are metalloenzymes responsible for catalyzing the reversible hydration of carbon dioxide to bicarbonate ions and protons. Among the various isoforms of carbonic anhydrases, CA IX is unique due to its restricted tissue distribution and its role in physiological responses to low oxygen levels, or hypoxia.
CA IX is primarily found on the cell surface and is highly expressed in certain tissues when they are exposed to hypoxic conditions. The expression of CA IX under hypoxia is predominantly regulated by the hypoxia-inducible factor (HIF) pathway. The enzyme plays a critical role in pH regulation in the hypoxic tumor microenvironment, helping cells adapt to acidic conditions by extruding bicarbonate ions and thus contributing to an alkaline intracellular pH. This function is vital for tumor cell survival and proliferation in hypoxic conditions, as it counteracts the potential detrimental effects of the acidic environment. CA IX activators, by promoting its activity or expression, can enhance this pH regulatory function. Understanding the mechanisms through which CA IX activators operate offers insights into cellular adaptation strategies under hypoxia. This knowledge elucidates the intricate balance cells strike to survive and thrive under challenging environmental conditions. By diving deep into the realm of CA IX activators, we can appreciate the adaptive capabilities of cells and the role of enzymes like CA IX in ensuring cellular homeostasis in dynamic environments.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Mimics hypoxia conditions, stabilizing hypoxia-inducible factor (HIF), which upregulates CA IX expression. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $255.00 | ||
Acts as an iron chelator and stabilizes HIF, leading to increased CA IX expression in response to simulated hypoxia. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
Inhibits prolyl hydroxylases, resulting in HIF stabilization and subsequent CA IX upregulation. | ||||||
Acriflavine | 8048-52-0 | sc-214489 sc-214489A | 25 g 100 g | $50.00 $171.00 | 2 | |
HIF inhibitor that can modulate CA IX expression by influencing HIF activity. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $33.00 $124.00 $218.00 $947.00 | 9 | |
Inhibits HIF, thereby potentially affecting CA IX expression. | ||||||
Quinomycin A | 512-64-1 | sc-202306 | 1 mg | $166.00 | 4 | |
Quenches HIF activity, which can influence CA IX expression levels. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Can induce hypoxia-like responses in cells, potentially upregulating CA IX through HIF stabilization. | ||||||
Protocatechuic acid | 99-50-3 | sc-205818 sc-205818A | 25 g 50 g | $132.00 $264.00 | 9 | |
Iron chelating agent that can stabilize HIF and upregulate CA IX. | ||||||
PX-478 | 685898-44-6 | sc-507409 | 10 mg | $175.00 | ||
HIF-1α inhibitor, which can modulate CA IX expression by altering HIF activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Destabilizes HIF-1α, which can influence CA IX expression. | ||||||