C9orf50 Inhibitors

Cyclosporin A, through its inhibition of calcineurin, affects T-cell activation and thus any proteins that are regulated by immune signaling pathways. 2-Methoxyestradiol disrupts microtubule dynamics, which could influence proteins involved in the cell cycle and intracellular transport. PD173074, as an FGFR inhibitor, has the capability to affect growth factor signaling, thereby potentially influencing proteins that are part of or regulated by this pathway. ZM-447439 inhibits Aurora kinases, which are key players in mitotic progression, and could thus have an impact on proteins associated with cell division. NSC 23766 targets the Rac1 GTPase, altering the actin cytoskeleton and potentially affecting proteins tied to cellular motility.

LY294002 inhibits PI3K, a central signaling molecule in pathways involved in cell survival and metabolism, thus affecting proteins regulated by this axis. SP600125, as a JNK inhibitor, influences stress response pathways and therefore the activity of proteins modulated by such pathways. Y-27632 inhibits ROCK, which plays a crucial role in cytoskeletal organization and cell adhesion, affecting associated proteins. SB431542 acts on TGF-beta receptors, influencing signaling pathways that regulate cell differentiation and proliferation, and can thus modulate relevant protein activity.