C8orf45 Inhibitors
The protein "minichromosome maintenance domain containing 2" (MCMDC2) is a member of the minichromosome maintenance (MCM) protein family, which plays a crucial role in DNA replication. MCM proteins are essential for the initiation and elongation phases of DNA replication, acting as helicases that unwind the DNA double helix to allow the replication machinery to access the single-stranded DNA.MCMDC2, while sharing some homology with other MCM proteins, has distinct features that suggest a specialized role within the cell. It contains the MCM domain, which is indicative of its participation in DNA metabolism, but the specific functions of MCMDC2 are not as well characterized as those of the canonical MCM2-7 complex that forms the replicative helicase core.
Research indicates that MCMDC2 may be involved in the regulation of DNA replication, possibly by interacting with other MCM proteins or with additional factors that govern the replication process. Its exact role in DNA replication initiation, progression, or termination, as well as its potential involvement in the response to DNA damage or replication stress, remains an active area of investigation.Understanding the function of MCMDC2 is crucial because the regulation of DNA replication is fundamental to maintaining genomic stability. Errors in replication can lead to mutations, which in turn can cause diseases, including cancer. Therefore, proteins like MCMDC2 are of significant interest in cell biology and medical research.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases (CDKs) which are necessary for the transition of cell cycle phases and indirectly affect the assembly of MCM complex. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine targets CDKs, which are crucial for the cell cycle progression, thereby potentially reducing the recruitment of MCM proteins to the origin of replication. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is a CDK inhibitor that may impede cell cycle progression, consequently downregulating the assembly of the pre-replication complex including MCMDC2. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a tetracycline antibiotic that selectively inhibits DNA polymerases, which might lead to a reduced need for MCM proteins in DNA replication. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function, potentially leading to cell cycle arrest and a subsequent decrease in MCM protein levels required for DNA synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can alter chromatin structure and gene expression, potentially diminishing MCMDC2 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane modulates transcription factors and can influence gene expression, which may include downregulation of replication-related proteins like MCMDC2. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, leading to DNA damage responses that could decrease the expression of genes involved in DNA replication such as MCMDC2. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide targets topoisomerase II, triggering DNA damage responses that can suppress the cell cycle and potentially reduce MCMDC2 expression. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C forms DNA crosslinks, resulting in DNA damage and possibly reduced expression of DNA replication proteins including MCMDC2. | ||||||