C7orf50 Activators
The class of C7orf50 activators comprises a diverse array of chemical compounds that exert their influence on the activation of the C7orf50 protein through direct or indirect mechanisms. One prominent group within this class includes phorbol esters, exemplified by PMA (Phorbol 12-myristate 13-acetate), which directly activates C7orf50 by stimulating the protein kinase C (PKC) pathway. By binding to and activating PKC, PMA initiates a cascade of events that modulate cellular responses, ultimately leading to the enhanced activation of C7orf50. Another subset of C7orf50 activators encompasses compounds like SB203580 and Forskolin, each influencing distinct cellular pathways to indirectly activate C7orf50. SB203580, a selective p38 MAPK inhibitor, relieves negative regulation on C7orf50 by suppressing the p38 MAPK pathway. Forskolin, on the other hand, stimulates adenylate cyclase, elevating cAMP levels and indirectly activating C7orf50 by influencing downstream signaling pathways.
Histone deacetylase inhibitors like Trichostatin A represent another category within the C7orf50 activator class. By inhibiting HDAC, Trichostatin A facilitates a more permissive chromatin environment, enhancing the transcriptional activation of C7orf50 and its involvement in cellular processes influenced by chromatin dynamics. Additionally, chemical compounds such as A769662, Calyculin A, 15d-PGJ2, BAY 11-7082, H-89, and DAPT contribute to this class of activators by modulating diverse signaling pathways, including AMP-activated protein kinase (AMPK), protein phosphatases, peroxisome proliferator-activated receptor gamma (PPARγ), NF-κB, protein kinase A (PKA), PI3K/Akt, and Notch, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates C7orf50 indirectly by stimulating the PKC pathway. PMA, a diester of phorbol, directly binds and activates PKC, leading to downstream signaling events that influence the cellular environment and modulate C7orf50. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK, and its inhibition indirectly activates C7orf50. By suppressing the p38 MAPK pathway, SB203580 relieves a negative regulatory influence on C7orf50, allowing for increased activation of the protein within the context of cellular signaling cascades. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, indirectly activates C7orf50 by influencing chromatin remodeling. By inhibiting HDAC, Trichostatin A promotes a more permissive chromatin environment, facilitating enhanced transcriptional activation of C7orf50 and its involvement in cellular processes. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMPK activator, indirectly influences C7orf50 activation by modulating cellular energy sensing. Activation of AMPK by A769662 leads to downstream effects on cellular metabolism, ultimately influencing the activation status of C7orf50 in response to energy-related signaling cascades. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, a protein phosphatase inhibitor, indirectly activates C7orf50 by affecting protein phosphorylation dynamics. Inhibition of protein phosphatases disrupts the balance of phosphorylation events, leading to altered signaling cascades that favor the activation of C7orf50 within the cellular context. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $141.00 $551.00 | 5 | |
15d-PGJ2, a natural ligand for PPARγ, indirectly activates C7orf50 by modulating PPARγ signaling. Binding to PPARγ influences downstream gene expression, including genes involved in cellular processes where C7orf50 plays a role, resulting in enhanced activation of C7orf50 in response to PPARγ-mediated signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082, an inhibitor of NF-κB activation, indirectly activates C7orf50 by suppressing NF-κB-mediated signaling. Inhibition of NF-κB removes a negative regulatory influence on C7orf50, allowing for increased activation of the protein within the context of cellular responses influenced by NF-κB signaling. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT, a γ-secretase inhibitor, indirectly activates C7orf50 by modulating Notch signaling. Inhibition of γ-secretase by DAPT alters Notch signaling, leading to downstream effects on cellular processes where C7orf50 plays a role, resulting in enhanced activation of C7orf50 in response to Notch pathway modulation. | ||||||