C2orf62 Inhibitors
Chemical inhibitors of the C2orf62 protein can act through various molecular mechanisms to impede its function. Phloretin disrupts glucose transportation by inhibiting glucose transporters, which can limit the energy supply necessary for C2orf62 activity. Genistein targets tyrosine kinases, enzymes that are crucial for the phosphorylation of proteins, a chemical process that can modify protein activity including that of C2orf62. Staurosporine, known for its broad kinase inhibition capabilities, can obstruct multiple kinase-driven pathways that might be vital for C2orf62 function. LY294002 and Wortmannin are both PI3K inhibitors; by hindering PI3K activity, they affect the signaling pathways that regulate various cellular processes, including those C2orf62 may be a part of, leading to a decrease in its activity.
Further affecting the signaling pathways, PD98059 and U0126 are inhibitors of MEK, which in turn is part of the MAPK/ERK pathway. This pathway plays a significant role in regulating the functions of proteins involved in cellular growth and survival, which includes C2orf62. SB203580 and SP600125 target different components of the MAPK signaling pathways, specifically p38 MAP kinase and JNK, respectively. Their inhibition can disrupt the regulatory mechanisms that control C2orf62 activity. Rapamycin impedes the mTOR pathway, which is central to cell growth and metabolism, affecting the cellular environment of C2orf62 function. Lastly, PP2 and NSC 23766 interfere with signaling processes that relate to the cytoskeletal dynamics and various cellular functions, with PP2 inhibiting Src family kinases and NSC 23766 targeting Rac1, both of which can influence the activity of the C2orf62 protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin inhibits glucose transporters (GLUTs), which are important for providing the energy necessary for various cellular functions. Inhibition of GLUTs can decrease the energy supply within the cell, potentially hindering the activity of C2orf62, which may require energy for its function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Tyrosine kinases are involved in the phosphorylation of proteins, a modification that can affect protein activity. By inhibiting these kinases, Genistein could reduce the phosphorylation and subsequent activation of C2orf62. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent kinase inhibitor, known to inhibit a broad range of kinases. It can inhibit kinase-mediated pathways essential for the activation or functioning of C2orf62, thereby leading to functional inhibition of the protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is part of signaling pathways that regulate various cellular processes, including those that C2orf62 may be involved in. Inhibition of PI3K can lead to reduced activity of downstream effectors that are necessary for C2orf62 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which blocks the MAPK/ERK pathway. This pathway can regulate protein functions involved in cellular growth and survival. By inhibiting this pathway, PD98059 could indirectly inhibit the function of C2orf62 by affecting its regulatory mechanisms. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. By blocking PI3K activity, it can impede the downstream signaling required for C2orf62 function, leading to its functional inhibition due to lack of necessary signaling for proper activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, a protein involved in inflammatory responses and stress. Inhibition of p38 MAP kinase can affect signaling pathways that potentially regulate C2orf62 activity, resulting in its functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. Inhibition of MEK by U0126 can disrupt the activation of ERK and its subsequent signaling, which may be necessary for the proper functioning of C2orf62. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the MAPK signaling pathways. JNK participates in controlling various cellular activities, and its inhibition could disrupt processes that are essential for the function of C2orf62. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism. By inhibiting mTOR, Rapamycin can decrease the cellular activities that are possibly critical for C2orf62 function, leading to its functional inhibition. | ||||||