C20orf43 Inhibitors

Replication Termination Factor 2, often abbreviated as RTF2, is a protein involved in the process of DNA replication, particularly in the termination phase. It plays a pivotal role in ensuring that the replication of the genome is accurately completed without stalling or errors, which is vital for maintaining genomic stability and preventing the accumulation of mutations that could lead to diseases such as cancer.RTF2 is characterized by its ability to bind to specific DNA sequences and structures that arise during the termination of DNA replication. Its function is associated with the recognition and resolution of converging replication forks, which are junctions where two opposing DNA replication complexes meet at the end of replicative events. RTF2 helps in disentangling these replication complexes, ensuring that the replication machinery can properly disassemble once the entire genome has been duplicated.

The importance of RTF2 is underscored by its conservation across various species, indicating that its role in replication termination is critical for cellular division and the propagation of genetic information. In eukaryotic cells, RTF2 is part of a larger terminus site-binding protein complex that recognizes termination sites and aids in the cessation of replication.While the exact mechanisms of RTF2's action are still under investigation, it is understood that the protein interacts with other replication factors and possibly with the replication machinery itself to signal the end of the replication process. This interaction ensures that the replication forks are not only stopped correctly but also that the newly synthesized DNA strands are properly processed and that any remaining replication proteins are removed from the DNA.