C1orf69 Inhibitors
C1orf69 inhibitors encompass a variety of chemical compounds that suppress the functional activity of C1orf69 through interactions with different signaling pathways or biological processes. For instance, Rapamycin, by inhibiting mTOR, a master regulator of cell growth and metabolism, potentially decreases C1orf69 activity if it is associated with these pathways. Similarly, proteasome inhibitor Bortezomib could impede C1orf69's role in protein degradation by preventing the normal turnover of proteins. If C1orf69 requires Hsp90 for its stability or function, the Hsp90 inhibitor 17-AAG would also reduce its activity by interfering with proper protein folding and function. Kinase inhibitors like Staurosporine and SP600125, which inhibit broad-spectrum kinases and JNK specifically, may diminish C1orf69's activity if it is regulated by phosphorylation through these kinases.
Further, PI3K inhibitors LY 294002 and Wortmannin would decrease C1orf69 activity by dampening the PI3K/Akt signaling pathway, assuming C1orf69 functions downstream of PI3K. The MEK inhibitors PD 98059 and U0126, by blocking the MAPK/ERK pathway, would reduce its activity if it is a downstream effector. Cyclopamine would inhibit the Hedgehog pathway, leading to reduced activity of C1orf69 if it is part of this pathway. Inhibition of p38 MAPK by SB 203580 could lead to decreased functional activity of C1orf69 in stress response signaling. Lastly, ZM-447439, as an Aurora kinase inhibitor, could suppress C1orf69 activity during cell cycle regulation if C1orf69 is dependent on Aurora kinase activity. Each inhibitor works by a distinct mechanism, but all converge on the common outcome of diminishing C1orf69's functional activity within its associated pathways.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can lead to a decrease in cellular proliferation and metabolism. If C1orf69 is involved in cell growth pathways, rapamycin-induced mTOR inhibition may diminish C1orf69's involvement in these processes. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A broad-spectrum protein kinase inhibitor known to suppress various signaling cascades. Its inhibition of certain kinases could lead to decreased phosphorylation and activity of C1orf69 if it is phosphorylation-dependent. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that diminishes the PI3K/Akt signaling pathway. If C1orf69 is active downstream of PI3K, LY294002 could reduce its activity by inhibiting this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor that blocks the MAPK/ERK pathway. If C1orf69 functions downstream of MEK, PD 98059's inhibition of MEK could result in the reduced activity of C1orf69. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A specific inhibitor of p38 MAPK. If C1orf69 is implicated in stress response pathways mediated by p38, inhibition by SB203580 would decrease C1orf69's functional activity. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
A Hedgehog signaling pathway inhibitor. If C1orf69 is part of the Hedgehog pathway, Cyclopamine would diminish its activity by disrupting this signaling cascade. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins. If C1orf69 is involved in protein degradation pathways, the inhibition of the proteasome could reduce its functional activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Another MEK inhibitor that prevents the activation of MAPK/ERK pathway. If C1orf69 operates within this pathway, U0126 would reduce its functional activity by blocking MEK. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor l, which could also diminish C1orf69 activity if it is downstream of PI3K/Akt signaling. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
An Hsp90 inhibitor which could decrease the stability and function of client proteins. If C1orf69 requires Hsp90 for proper folding or function, 17-AAG could diminish its activity. | ||||||