Chromosome 1 open reading frame 127, abbreviated as C1orf127, is a gene located on the first chromosome in humans. As an "open reading frame" (ORF), it denotes a stretch of DNA that is predicted to encode a protein. C1orf127's designation implies that it has been identified through genomic sequencing as a potential protein-coding region, but it does not necessarily mean that its function is well understood. The protein encoded by C1orf127 is presumed to have a specific role within the cellular context, which could be structural, regulatory, enzymatic, or signaling-related, among other possibilities. Like many ORFs identified through genomic projects, C1orf127 requires additional research to elucidate its function.
Typically, a gene like C1orf127 would be investigated by examining its expression pattern in various tissues and at different developmental stages. This would provide clues to its potential role in the body. Expression studies might be complemented with subcellular localization assays to determine where within the cell the C1orf127 protein functions.Furthermore, the study of protein domains and motifs within the C1orf127 sequence can provide insights into possible molecular functions or interactions with other proteins. Researchers may also employ techniques like gene knockout or knockdown in model organisms or cell lines to observe the biological effects of losing the protein's function, which can be particularly revealing.In summary, C1orf127 represents a genomic locus on chromosome 1 with the capacity to encode a protein, the function of which remains to be characterized through empirical research. Such genes are often points of interest for molecular biologists seeking to uncover new aspects of cellular function and the genetic underpinnings of human biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide downregulates various transcription factors, potentially decreasing C1orf127 mRNA synthesis. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and prevents the transcription initiation, which could inhibit C1orf127 transcription. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin inhibits RNA polymerase II, which is essential for mRNA synthesis, thus could reduce C1orf127 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into RNA, impairing ribosomal function and could decrease C1orf127 protein production. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine disrupts lysosomal function, which could lead to altered degradation pathways affecting C1orf127 stability. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits the proteasome, potentially causing reduced degradation of proteins that regulate C1orf127 expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II elongation, which could suppress C1orf127 mRNA elongation. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C forms DNA adducts, which could interfere with C1orf127 gene transcription. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, blocking DNA unwinding necessary for C1orf127 gene transcription. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Puromycin causes premature chain termination during translation, which could reduce C1orf127 protein levels. | ||||||