C19orf54 represents a gene of interest within the complex network of human genetics, the expression of which contributes to various molecular functions within the cell. While the exact role of C19orf54 remains an area of active investigation, research suggests that it may play a significant part in cellular processes, possibly including gene regulation, signal transduction, or intracellular transport. Understanding the regulation of this gene is crucial, especially in the context of genetic research where modulating gene expression can lead to insights into gene function and its role in the broader cellular context. The intricate control of gene expression is a symphony of numerous factors, with transcription factors, enhancers, silencers, and epigenetic modifications each playing their part. Given the complexity of these regulatory elements, researchers have developed an interest in identifying chemical compounds that can selectively inhibit the expression of specific genes like C19orf54.
In the quest to explore the regulation of C19orf54, a spectrum of chemical compounds has emerged as potential inhibitors of its expression. These chemicals operate through diverse mechanisms to downregulate the transcriptional activity of the gene. For instance, some compounds may bind directly to the DNA, blocking the transcription machinery physically and preventing the initiation or elongation of mRNA synthesis. Others interact with the epigenetic landscape, modifying DNA methylation or histone acetylation patterns to either expose or conceal the gene from transcriptional activators. Additionally, some molecules may inhibit key enzymes that are essential for transcription factor activation, thereby indirectly leading to a reduction in C19orf54 expression. The array of potential inhibitors includes molecules with varied biological origins and chemical structures, each offering a unique angle of interference with the gene's expression. The exploration of these compounds provides a valuable toolkit for researchers to dissect the functional importance of C19orf54 and to further our understanding of the genetic mechanisms that govern cellular homeostasis.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin′s intercalative properties may disrupt the transcriptional machinery at the C19orf54 gene locus, leading to a decrease in its mRNA synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase, Trichostatin A could induce hyperacetylation of histones, resulting in a closed chromatin conformation at the C19orf54 promoter, thereby silencing its transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
The hypomethylation of DNA caused by 5-Azacytidine may lead to the repression of C19orf54 expression by altering the binding affinity of transcription factors or co-repressors to the gene's promoter region. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D's binding to guanine residues could obstruct RNA polymerase access to the C19orf54 gene, effectively inhibiting its transcription. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide may downregulate C19orf54 expression by hindering the assembly of the transcriptional machinery at the gene′s promoter, potentially through the covalent modification of transcription factors. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
By inhibiting cyclin-dependent kinases, Flavopiridol could compromise the phosphorylation state of transcriptional machinery, leading to a reduction in the elongation phase of C19orf54 transcription. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine may disrupt endosomal sorting and lysosomal degradation pathways, which could indirectly lead to the stabilization of transcriptional repressors and a consequent decrease in C19orf54 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine (Decitabine) could initiate DNA demethylation at the C19orf54 gene promoter, potentially recruiting transcriptional repressors that downregulate gene expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1's binding to BET bromodomains may prevent the recruitment of positive transcriptional regulators to the C19orf54 promoter, leading to a decrease in gene transcription. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-amanitin may inhibit RNA polymerase II directly, sharply reducing the transcription of C19orf54 by preventing mRNA chain elongation. |