C18orf20 Inhibitors

Long intergenic non-protein coding RNA 305 (LINC00305) is a member of the long non-coding RNA (lncRNA) family, which is a diverse class of transcripts that do not encode proteins but play crucial roles in regulating gene expression at various levels, including chromatin modification, transcription, and post-transcriptional processing. LncRNAs like LINC00305 are characterized by their length, typically exceeding 200 nucleotides, and their lack of a significant open reading frame capable of producing functional proteins.LINC00305, as its category suggests, is located within genomic regions between protein-coding genes, highlighting its potential role in the complex network of gene regulation. It is transcribed by RNA polymerase II and is polyadenylated, bearing similarities to mRNA in terms of its synthesis and processing, yet it does not travel the typical path towards encoding a protein.

The functions of LINC00305 are not completely understood, but lncRNAs are known to be involved in a variety of biological processes, including cell growth, differentiation, and apoptosis. LINC00305 may exert its effects through diverse mechanisms such as acting as a scaffold for ribonucleoprotein complexes, serving as a guide for chromatin-modifying enzymes to specific genomic loci, functioning as a molecular decoy for splicing factors or microRNAs, or influencing nuclear architecture and dynamics.Research suggests that LINC00305 may play a role in certain disease states, including various cancers, where its expression might be dysregulated. In such contexts, LINC00305 could affect tumorigenesis, metastasis, and cancer cell survival by modulating the activity of genes involved in these processes.