C12orf24 Inhibitors
Chemical inhibitors of C12orf24 employ various mechanisms to suppress its function within cellular signaling pathways. LY294002 and Wortmannin are potent inhibitors of phosphoinositide 3-kinases (PI3Ks), which are key enzymes that activate signaling cascades, including the AKT pathway. By inhibiting PI3K, these chemicals can reduce the phosphorylation and activation of downstream effectors linked to C12orf24's function. Similarly, the specific mTOR inhibitor Rapamycin disrupts the mTOR signaling cascade, which is also downstream of PI3K/AKT. This inhibition is crucial since mTOR is a central regulator of cell growth and proliferation, and its suppression can affect C12orf24 if it plays a role in these processes. Furthermore, SB203580 targets p38 MAP kinase, a molecule that responds to stress signals. If C12orf24 functions within the p38 MAPK pathway, SB203580's action would lead to its functional inhibition.
Continuing with the theme of kinase inhibition, SP600125 disrupts c-Jun N-terminal kinase (JNK) signaling, which could lead to the functional inhibition of C12orf24 if it is involved in the JNK pathway, often associated with cell stress responses. Similarly, U0126 and PD98059 are both MEK inhibitors, which directly affect the ERK pathway, an important signaling mechanism for cell division and differentiation. Inhibition of MEK1/2 by these compounds would also suppress C12orf24 if it is part of the ERK pathway. ZM-447439, on the other hand, is an Aurora kinase inhibitor, which can impede C12orf24's function if it is involved in controlling mitotic processes. Additionally, Palbociclib's selective inhibition of CDK4/6 interrupts cell cycle progression, which could lead to the functional inhibition of C12orf24 if it is linked to cell cycle regulation. Nutlin-3, which disrupts the MDM2-p53 interaction, can also modulate C12orf24's activity by stabilizing p53, a protein that regulates the cell cycle and apoptosis. Lastly, inhibitors such as Olaparib, which targets PARP enzymes involved in DNA repair, and Venetoclax, a Bcl-2 inhibitor that induces apoptosis, can functionally inhibit C12orf24 if it is associated with DNA repair or survival pathways regulated by these targets.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Inhibition of PI3K can lead to reduced phosphorylation and activation of downstream effectors such as AKT, which in turn can lead to the functional inhibition of C12orf24 if C12orf24 is part of PI3K/AKT signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that irreversibly binds to and inhibits the activity of PI3K. This inhibition can lead to the functional suppression of C12orf24 if it operates within the PI3K/AKT pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin specifically inhibits mTOR, which is a downstream target of the PI3K/AKT pathway. By inhibiting mTOR, Rapamycin can suppress the mTOR signaling cascade, which can functionally inhibit C12orf24 if it is involved in this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. The p38 MAPK pathway is involved in cellular responses to stress and inflammation. Inhibition of p38 MAP kinase by SB203580 can lead to functional inhibition of C12orf24 if it is implicated in p38 MAPK pathway signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 acts as an inhibitor of c-Jun N-terminal kinase (JNK). Inhibition of JNK signaling can lead to functional inhibition of C12orf24 if it is linked to JNK signaling pathways involved in cell stress and apoptosis. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 selectively inhibits MEK1/2, which are upstream regulators of the ERK pathway. By inhibiting MEK, U0126 can suppress ERK pathway signaling, which can lead to functional inhibition of C12orf24 if it is associated with this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that blocks the activation of MEK1/2 by upstream kinases. This can result in the functional inhibition of C12orf24 if it is part of the ERK signaling cascade that regulates various cellular processes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Aurora kinases are involved in the regulation of mitosis. By inhibiting Aurora kinases, ZM-447439 can functionally inhibit C12orf24 if it has a role in cell cycle progression and mitosis. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Palbociclib is a selective inhibitor of CDK4/6, which are critical for cell cycle G1 phase progression. Inhibition of CDK4/6 by Palbociclib can lead to functional inhibition of C12orf24 if it is involved in cell cycle regulation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 is an inhibitor of the MDM2-p53 interaction. By preventing MDM2 from binding and degrading p53, Nutlin-3 can enhance p53 activity which can lead to functional inhibition of C12orf24 if it is regulated by p53-mediated signaling. | ||||||