C11orf93 Inhibitors
C11orf9 inhibitors constitute a chemically diverse group of compounds that can indirectly reduce the functional activity of C11orf9 by targeting various signaling pathways and biological processes. For instance, the inhibition of mTOR by rapamycin could indirectly downregulate C11orf9 if it is involved in mTOR-mediated cellular processes. Similarly, staurosporine's broad kinase inhibition might decrease C11orf9 activity through reduced phosphorylation-dependent signaling, assuming C11orf9 is regulated by such mechanisms. Furthermore, the modulation of immune response by calcitriol, through the downregulation of pro-inflammatory cytokines, could lead to a decrease in C11orf9 activity if it is associated with inflammatory pathways.
The influence of these inhibitors on C11orf9 extends to the transcriptional level, where dexamethasone's activation of the glucocorticoid receptor can suppress inflammatory gene expression, potentially affecting C11orf9 if it is involved in inflammation. Histone deacetylase inhibition by trichostatin A alters gene expression patterns, which might impact C11orf9 expression. In cellular metabolism, compounds like 2-Deoxy-D-glucose disrupt glycolysis, which could reduce the activity of C11orf9 if it relies on energy-intensive processes. The effectiveness of these compounds in inhibiting C11orf9 underscores the protein's potential involvement in a variety of cellular functions and the complex nature of its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
Calcitriol is an active form of vitamin D that modulates calcium and phosphate homeostasis. It inhibits the proliferation of pro-inflammatory cytokines, which can indirectly diminish the activity of C11orf9 by reducing inflammatory signaling pathways that might otherwise enhance the stability or activity of C11orf9. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. mTOR signaling is implicated in a variety of cellular processes, including survival and proliferation. Inhibition of mTOR can lead to downregulation of proteins involved in these pathways, potentially including C11orf9, by hampering the processes that C11orf9 may be involved in. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a non-specific protein kinase inhibitor. By broadly inhibiting kinases, staurosporine can lead to decreased phosphorylation and activation of signaling proteins, possibly reducing the activity or stability of C11orf9 if it is regulated by phosphorylation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist. It regulates gene expression by activating the glucocorticoid receptor, which can suppress the expression of multiple inflammatory genes and potentially decrease the activity of C11orf9 if it is upregulated in inflammatory conditions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By preventing deacetylation of histones, it can change the expression patterns of genes, possibly leading to reduced expression or activity of C11orf9 if it is regulated by acetylation-related transcriptional changes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is part of the AKT signaling pathway, which is involved in cell survival and growth. Inhibition of this pathway can lead to decreased cell survival signals and potentially reduce the activity of C11orf9 if its function is associated with these cell survival pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to inhibit NF-κB, a transcription factor that is a pivotal player in inflammatory responses. By inhibiting NF-κB, curcumin can lead to the reduced activity of proteins regulated by this transcription factor, potentially including C11orf9 if it is a target of NF-κB signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, key components of the MAPK/ERK pathway. Inhibition of this pathway can result in decreased cell proliferation and differentiation signals, which could indirectly affect the activity of C11orf9 if it is involved in these signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor, functioning similarly to U0126. It could lead to a decrease in the functional activity of C11orf9 by inhibiting the pathways that regulate its activity or expression. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium Salicylate inhibits NF-κB similarly to curcumin and can suppress inflammatory pathways. This could lead to the downregulation of proteins such as C11orf9 that may be upregulated in response to inflammation. | ||||||