C11orf48 Activators
C11orf48 initiate various intracellular signaling pathways leading to its functional activation. Phorbol 12-myristate 13-acetate (PMA) mimics diacylglycerol (DAG) and stimulates protein kinase C (PKC), which can phosphorylate C11orf48. Similarly, Forskolin raises cyclic AMP (cAMP) levels by directly activating adenylyl cyclase, which in turn activates protein kinase A (PKA). PKA can phosphorylate a wide range of proteins, including C11orf48. Ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent kinases, such as calmodulin-dependent kinase, which can also lead to the phosphorylation of C11orf48.
Epidermal Growth Factor (EGF), by binding to its receptor, triggers the MAPK/ERK pathway, which can result in the phosphorylation of C11orf48. Insulin engages its receptor and sets off a series of phosphorylation events, including the activation of the PI3K/AKT pathway, which can further phosphorylate C11orf48. Brain-derived neurotrophic factor (BDNF) activates the TrkB receptors leading to the PI3K/AKT pathway activation, which can also phosphorylate C11orf48. Anisomycin activates stress-activated protein kinases such as JNK, which can target C11orf48 for phosphorylation. Inhibitors of protein phosphatases like Calyculin A and Okadaic Acid prevent dephosphorylation, thereby maintaining proteins such as C11orf48 in a phosphorylated state. Retinoic Acid can alter gene expression and upregulate kinases that can phosphorylate C11orf48. Hydrogen Peroxide, as a reactive signaling molecule, can lead to the activation of C11orf48 through oxidative modifications. Lastly, Sphingosine-1-phosphate (S1P) binds to its receptors to activate ERK and PI3K/AKT pathways, which can phosphorylate and activate C11orf48.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol esters like PMA act as diacylglycerol (DAG) analogs, activating protein kinase C (PKC), which in turn can phosphorylate and lead to the functional activation of C11orf48 if it is a substrate of PKC. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore, raising intracellular calcium levels, which can activate calcium-dependent protein kinases such as calmodulin-dependent kinase that might phosphorylate and thus functionally activate C11orf48. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor activation initiates a cascade of phosphorylation events, including the PI3K/AKT pathway, which could lead to the phosphorylation and functional activation of C11orf48 as part of its signaling. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases like JNK, which could phosphorylate and thereby activate C11orf48 if it is a target of these kinases. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, which leads to increased phosphorylation levels of proteins, which might include C11orf48, resulting in its activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits protein phosphatases, leading to a net increase in protein phosphorylation which could activate C11orf48 if it is normally regulated by dephosphorylation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate signaling pathways by altering gene expression, which may lead to the upregulation of kinases or other activating molecules that functionally activate C11orf48. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide is a reactive oxygen species that can act as a signaling molecule, potentially leading to the oxidation and modification of signaling proteins, which may include the activation of C11orf48. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P binds to its G-protein-coupled receptors, which can activate downstream kinases such as ERK and PI3K/AKT, potentially leading to the phosphorylation and activation of C11orf48 as part of the signaling response. | ||||||