C030046I01Rik Inhibitors
Chemical inhibitors of C030046I01Rik employ various mechanisms to dampen the activity of this protein by targeting different signaling pathways and enzymatic activities. Bisindolylmaleimide I, for instance, is a selective inhibitor of protein kinase C (PKC), a family of enzymes that are pivotal in numerous cellular processes. By inhibiting PKC, Bisindolylmaleimide I can reduce the phosphorylation events that are essential for C030046I01Rik's function. Similarly, LY294002 and Wortmannin exert their inhibitory effects on C030046I01Rik by impeding the phosphoinositide 3-kinase (PI3K) pathway, which is crucial for the activation and phosphorylation states required by C030046I01Rik. PD98059 and U0126, both of which are selective for mitogen-activated protein kinase kinase (MEK), prevent the activation of the extracellular signal-regulated kinase (ERK) pathway, potentially diminishing the functional activity of C030046I01Rik that is dependent on this signaling cascade.
On another front, SB203580 and SP600125 target the p38 MAP kinase and c-Jun N-terminal kinase (JNK) pathways, respectively. By obstructing these pathways, these inhibitors can reduce the functional activity of C030046I01Rik that relies on p38 MAPK and JNK signaling. Rapamycin, an mTOR inhibitor, inhibits C030046I01Rik by interfering with the mTOR signaling pathway, which is another critical regulator of cellular functions and is implicated in the control of C030046I01Rik activity. In the realm of tyrosine kinase activity, PP2 comes into play by selectively inhibiting Src family tyrosine kinases, which are involved in various signaling pathways that can regulate the activity of C030046I01Rik. Meanwhile, Y-27632 targets the Rho-associated protein kinase (ROCK), and by doing so, it can reduce the ROCK-mediated signaling processes that may be important for C030046I01Rik's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a potent and selective inhibitor of protein kinase C (PKC), which can inhibit C030046I01Rik by reducing PKC-mediated phosphorylation events that are critical for the protein's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor, which can inhibit C030046I01Rik by blocking the PI3K/AKT pathway, potentially reducing the phosphorylation and activation states that C030046I01Rik requires for its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which can inhibit C030046I01Rik by preventing the activation of the extracellular signal-regulated kinase (ERK) pathway, a pathway C030046I01Rik may rely on for its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase, which can inhibit C030046I01Rik by blocking the p38 MAPK signaling pathway, potentially reducing the protein's functional activity that depends on this signaling pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which can inhibit C030046I01Rik by obstructing the JNK signaling pathway, potentially diminishing the functional activity of C030046I01Rik linked to this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, which can inhibit C030046I01Rik by obstructing mTOR signaling, potentially decreasing the functional activity of C030046I01Rik that is modulated by the mTOR pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, which can inhibit C030046I01Rik by blocking the PI3K/AKT pathway, potentially reducing the phosphorylation and activation states that C030046I01Rik requires for its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor, which can inhibit C030046I01Rik by preventing the activation of the ERK pathway, which may be essential for the function of C030046I01Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases, which can inhibit C030046I01Rik by reducing Src kinase-mediated phosphorylation that could be crucial for C030046I01Rik's activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of the Rho-associated protein kinase (ROCK), which can inhibit C030046I01Rik by reducing ROCK-mediated signaling processes that may be important for the protein's function. | ||||||