C/EBP ζ Activators
C/EBP ζ activators encompass a range of chemical compounds that indirectly promote the functional activity of C/EBP ζ through diverse signaling pathways. Compounds like Forskolin and IBMX increase intracellular cAMP levels, which activate PKA, a kinase that can phosphorylate and thereby enhance the transcriptional activity of C/EBP ζ. Similarly, PGE2, through its interaction with G-protein-coupled receptors, raises cAMP levels, serving the same purpose. LiCl's inhibition of GSK-3 stabilizes C/EBP ζ by preventing its phosphorylation-based suppression, while AICAR activates AMPK, which may enhance C/EBP ζ activity through the phosphorylation of associated transcription factors and coactivators. PMA, a PKC activator, and Oleic Acid, a PPAR activator, may also enhance the DNA-binding activity of C/EBP ζ through direct phosphorylation or by upregulating its expression, respectively.
Rosiglitazone, another PPAR agonist, and Dexamethasone, a glucocorticoid, potentially upregulate C/EBP ζ by activating their respective receptor pathways, which may have response elements in the C/EBP ζ gene promoter. Curcumin, by inhibiting competitive NF-κB signaling, indirectly promotes C/EBP ζ activity by reducing the repression of its target genes. Retinoic Acid and ZnSO4 act by binding to nuclear receptors and as a structural component, respectively, both contributing to the proper function and activity of C/EBP ζ. Collectively, these compounds enhance the transcriptional activity of C/EBP ζ by influencing a variety of signaling pathways and cellular processes, ensuring a multifaceted approach to the activation of this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (Protein Kinase A), which can phosphorylate transcription factors, including C/EBP ζ, thereby enhancing its transcriptional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which degrade cAMP and cGMP. By preventing cAMP degradation, IBMX indirectly increases PKA activity, which can enhance the phosphorylation and activation of C/EBP ζ. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 interacts with its G-protein-coupled receptors, leading to increased intracellular cAMP and activation of PKA. PKA can then phosphorylate C/EBP ζ, leading to its enhanced activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which can phosphorylate certain residues on C/EBP ζ, potentially enhancing its DNA-binding activity and transcriptional efficacy. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits GSK-3, a kinase that can phosphorylate and inhibit various transcription factors. Inhibition of GSK-3 could stabilize and activate C/EBP ζ by preventing its phosphorylation-based suppression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an activator of AMPK, which can lead to the phosphorylation of transcription factors and coactivators that work with C/EBP ζ, enhancing its transcriptional activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
As a PPARγ agonist, Rosiglitazone can upregulate the expression of C/EBP ζ by binding to PPAR response elements in the regulatory regions of genes, including those encoding for C/EBP family proteins. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid can activate peroxisome proliferator-activated receptors (PPARs) which may enhance the expression of C/EBP ζ by binding to PPAR response elements in the C/EBP ζ gene promoter. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can enhance the activity of C/EBP ζ by glucocorticoid response elements which may increase the expression of genes under C/EBP ζ control. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which may reduce the repression of genes controlled by C/EBP ζ, leading to an indirect enhancement of C/EBP ζ's functional activity. | ||||||