BY080835 Activators
Lsmem2, or Leucine-rich single-pass membrane protein 2, plays a crucial role in cellular processes through its known or predicted functions. This transmembrane protein is intricately involved in diverse signaling pathways, contributing to cellular differentiation, proliferation, and homeostasis. Lsmem2's primary function is linked to its modulation of various downstream effectors, making it a key player in cellular responses to external stimuli.
Activation of Lsmem2 involves intricate molecular interactions influenced by specific chemicals targeting diverse cellular pathways. Retinoic Acid indirectly activates Lsmem2 by modulating retinoic acid receptors, impacting gene expression in downstream pathways. Forskolin stimulates Lsmem2 activation through increased cAMP levels, triggering protein kinase A (PKA) activation. Additionally, 2-Aminoethoxydiphenyl ether disrupts the PI3K/Akt pathway, leading to indirect activation of Lsmem2. JNK Inhibitor II, Sulindac, Niclosamide, BAY 11-7082, Wortmannin, SB 203580, NSC 23766, SP600125, and PD 98059 act as indirect activators by modulating various signaling pathways, ultimately influencing cellular environments and contributing to Lsmem2 activation. These chemicals collectively provide a comprehensive view of potential modulators for Lsmem2, shedding light on the intricate network of molecular interactions governing its activation. The multifaceted role of Lsmem2 in cellular processes highlights the significance of understanding its activation mechanisms, paving the way for further research into targeted interventions and potential applications in cellular regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid activates Lsmem2 indirectly by modulating retinoic acid receptors (RARs), altering gene expression in downstream pathways. RARs regulate cellular differentiation, and their modulation influences the cellular environment, promoting Lsmem2 activation through intricate signaling cascades. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates Lsmem2 activation by increasing intracellular cAMP levels, triggering protein kinase A (PKA) activation. Activated PKA phosphorylates downstream targets, influencing cellular processes that ultimately activate Lsmem2. The cAMP/PKA pathway serves as a signaling nexus, mediating indirect activation of Lsmem2 through intricate molecular interactions. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB ether acts as an indirect activator by disrupting the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Inhibition of this pathway influences downstream effectors, modulating cellular processes that contribute to the activation of Lsmem2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK Inhibitor II indirectly activates Lsmem2 by suppressing c-Jun N-terminal kinase (JNK) activity. Inhibition of JNK alters downstream signaling cascades, impacting cellular processes that contribute to Lsmem2 activation. The compound's modulation of JNK signaling intricately connects to Lsmem2 activation, establishing a molecular link between their biochemical interactions. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac indirectly activates Lsmem2 by inhibiting cyclooxygenase (COX) activity, leading to decreased prostaglandin production. The reduction in prostaglandins influences cellular processes, ultimately contributing to Lsmem2 activation through intricate signaling cascades. The compound's impact on COX pathways establishes a molecular link between its biochemical interactions and the activation of Lsmem2. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide serves as an indirect activator by modulating Wnt/β-catenin signaling. Inhibition of this pathway affects downstream processes, influencing cellular environments that contribute to the activation of Lsmem2. The compound's impact on Wnt/β-catenin signaling establishes a molecular link between its biochemical interactions and the activation of Lsmem2. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 acts as an indirect activator by inhibiting NF-κB signaling. Suppression of NF-κB alters downstream processes, influencing cellular environments that contribute to the activation of Lsmem2. The compound's impact on NF-κB signaling establishes a molecular link between its biochemical interactions and the activation of Lsmem2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin serves as an indirect activator by inhibiting phosphoinositide 3-kinase (PI3K) activity. Inhibition of PI3K affects downstream processes, influencing cellular environments that contribute to the activation of Lsmem2. The compound's impact on PI3K pathways establishes a molecular link between its biochemical interactions and the activation of Lsmem2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 indirectly activates Lsmem2 by inhibiting p38 MAPK activity. Suppression of p38 MAPK alters downstream processes, influencing cellular environments that contribute to the activation of Lsmem2. The compound's impact on p38 MAPK signaling establishes a molecular link between its biochemical interactions and the activation of Lsmem2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 acts as an indirect activator by inhibiting MEK1/2 activity. Suppression of MEK1/2 alters downstream processes, influencing cellular environments that contribute to the activation of Lsmem2. The compound's impact on MEK1/2 signaling establishes a molecular link between its biochemical interactions and the activation of Lsmem2. | ||||||