BTBD16 Activators
BTBD16 activators form a niche class of chemical compounds that interact with the BTBD16 protein, a member of the broad and functionally diverse BTB (BR-C, ttk, and bab) domain-containing protein family. The BTB domain, also known as the POZ domain, is a versatile protein-protein interaction motif that is implicated in a wide range of cellular functions. BTBD16 activators are designed to modulate the function of the BTBD16 protein, which can have various downstream effects on cellular mechanisms. The specific biochemical pathways and interactions in which BTBD16 is involved are intricate, involving the regulation of protein degradation, cytoskeletal dynamics, and transcriptional regulation, to name a few. The activators themselves are typically small molecules, which can permeate cellular membranes and selectively bind to the BTBD16 protein, thereby affecting its activity.
The discovery and development of BTBD16 activators involve a complex process of molecular design, synthesis, and analysis to ensure specificity and effectiveness in engaging with the BTBD16 protein. Researchers utilize a range of techniques, including high-throughput screening, computational modeling, and structure-activity relationship studies, to identify and optimize these activators. The chemical structure of BTBD16 activators is often characterized by the presence of functional groups that facilitate interaction with the targeted protein domain and the modulation of its activity. These activators are the result of extensive research into the molecular architecture of BTBD16, aiming to leverage specific binding interactions that can modulate the protein's function. The activators' design is informed by an understanding of the protein's three-dimensional structure and the dynamic nature of its interaction with other cellular components. As a result, the specificity and selectivity of these compounds are of paramount importance in their development, ensuring that they precisely engage with BTBD16 without off-target effects on other proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cyclic AMP (cAMP) levels, which in turn activates protein kinase A (PKA). PKA can phosphorylate a multitude of proteins, potentially including BTBD16, thereby enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC), which may lead to the phosphorylation of BTBD16 or associated proteins, enhancing BTBD16's activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, potentially activating calcium-dependent protein kinases that could phosphorylate BTBD16, enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibitory activity. It may inhibit kinases that negatively regulate BTBD16, leading to an enhancement of BTBD16 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors, which can lead to downstream signaling events that enhance BTBD16's activity through kinase cascades. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPK), leading to the activation of signaling pathways that could enhance the functional activity of BTBD16. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA, potentially leading to the phosphorylation and activation of BTBD16. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a stable cAMP analog that activates PKA, potentially leading to enhanced BTBD16 activity through phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased protein phosphorylation and potentially enhancing the activity of BTBD16 through reduced dephosphorylation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased intracellular calcium levels, which could activate calcium-sensitive signaling pathways affecting BTBD16's function. | ||||||