Brn-2 Inhibitors
Common Brn-2 Inhibitors include, but are not limited to Xanthohumol from hop (Humulus lupulus) CAS 6754-58-1, Oridonin, R. rubescens CAS 28957-04-2, Curcumin CAS 458-37-7, SF1126 CAS 936487-67-1 and Salinomycin CAS 53003-10-4.
Brn-2 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Brn-2, also known as POU3F2 or N-Oct-3. Brn-2 is a transcription factor belonging to the POU-domain family, which plays a critical role in the regulation of gene expression during neural development and differentiation. It is involved in the specification of neuronal and glial cell types and is important for maintaining the balance between self-renewal and differentiation of neural progenitor cells.
Brn-2 inhibitors work by specifically targeting the Brn-2 transcription factor, interfering with its ability to bind to specific DNA sequences and regulate the expression of target genes. By doing so, these inhibitors may modulate the transcriptional programs that guide neural development and influence the fate of neural precursor cells. Research into Brn-2 inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in understanding neural development and cellular differentiation. The study of Brn-2 inhibitors contributes to a deeper understanding of the intricate mechanisms governing neural fate determination and cellular identity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Xanthohumol from hop (Humulus lupulus) | 6754-58-1 | sc-301982 | 5 mg | $361.00 | 1 | |
Xanthohumol is a natural compound found in hops. It has been suggested to inhibit Brn-2 by interfering with its transcriptional activity. Xanthohumol may modulate downstream target genes regulated by Brn-2, affecting its role in cell differentiation and tumorigenesis. | ||||||
Oridonin, R. rubescens | 28957-04-2 | sc-202751 | 5 mg | $77.00 | ||
Oridonin is a natural diterpenoid compound with potential anti-cancer properties. It has been proposed to suppress Brn-2 expression and its transcriptional activity, leading to the modulation of downstream pathways that contribute to cell proliferation and invasion in certain cancers. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound with anti-inflammatory and anti-cancer properties. It has been suggested to modulate Brn-2 expression and activity, potentially affecting its role in promoting cell survival and proliferation in certain cancer contexts. | ||||||
SF1126 | 936487-67-1 | sc-391584 sc-391584A | 5 mg 10 mg | $1050.00 $2240.00 | 7 | |
SF1126 is a small molecule that can potentially inhibit PI3K, which is involved in cell signaling pathways. Since Brn-2 can be influenced by signaling pathways, targeting PI3K with SF1126 might indirectly impact Brn-2 expression and its downstream effects on cell behavior. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol, has been proposed to affect Brn-2 expression and its downstream targets in cancer cells. Its mechanisms of action might involve modulation of signaling pathways that intersect with Brn-2's functions, contributing to changes in cell behavior. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that can potentially disrupt Brn-2's interaction with chromatin and other protein partners. This interference with Brn-2's binding could lead to altered gene expression patterns and subsequently impact cell differentiation and proliferation processes. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
Salinomycin, an antibiotic, has been explored for its anti-cancer properties. It may impact Brn-2 expression and function, potentially by affecting cellular signaling pathways that intersect with Brn-2's activity and contributing to changes in cell behavior and survival. | ||||||