Brm Activators
Bromodomain (BrD) activators, also known as Brm activators, represent a specialized class of small molecules that exert their influence at the molecular level within the realm of epigenetics. Epigenetics refers to the study of heritable changes in gene expression that do not involve alterations to the DNA sequence itself but rather modifications to the chromatin structure, which encompasses DNA wrapped around histone proteins. Specifically, Brm activators target a specific class of proteins known as bromodomain-containing proteins, which are key players in the regulation of gene expression. These proteins possess bromodomains, specialized modules that recognize and bind to acetylated lysine residues on histone proteins, enabling them to act as transcriptional co-regulators.
Brm activators, as the name suggests, enhance the activity of bromodomain-containing proteins by promoting their binding to acetylated histones. This interaction, facilitated by the activator molecules, leads to a cascade of events that can modulate gene expression. By augmenting the recognition and binding of bromodomains to acetylated histones, Brm activators can potentiate or attenuate gene transcription, depending on the specific context. This fine-tuning of gene expression plays a crucial role in various cellular processes, including cell differentiation, proliferation, and response to environmental cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, potentially leading to demethylation of the BRM promoter region and its activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, it may enhance the acetylation of histones, facilitating an open chromatin state and potentially upregulating BRM expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
This natural compound has been shown to modulate various signaling pathways, possibly leading to the induction of BRM expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known for its anti-inflammatory effects, curcumin may influence epigenetic modifications, potentially resulting in the upregulation of BRM. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
As a derivative of vitamin A, retinoic acid influences cell differentiation and growth, possibly affecting BRM expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
It plays a role in gene expression regulation and cell growth, potentially influencing the expression of BRM. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
This estrogen hormone can bind to its receptor and modulate gene expression, potentially leading to the upregulation of BRM. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a synthetic glucocorticoid, it can modulate gene expression and might have an effect on BRM expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Known for its stimulatory effects, caffeine has also been implicated in the modulation of various signaling pathways, potentially influencing BRM expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Found in cruciferous vegetables, this compound has been shown to have a role in epigenetic modulation, potentially leading to the induction of BRM expression. | ||||||