Date published: 2026-4-5

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BRD Inhibitors

Santa Cruz Biotechnology now offers a broad range of BRD Inhibitors for use in various applications. BRD inhibitors, which target bromodomain and extra-terminal (BET) proteins, are a significant category of compounds in scientific research, particularly in the study of gene expression regulation and epigenetics. BET proteins, which include BRD2, BRD3, BRD4, and BRDT, play a critical role in reading acetylated lysine residues on histone tails, thereby influencing chromatin structure and transcriptional activation. By inhibiting these proteins, researchers can explore the mechanisms by which BRD proteins regulate gene expression, offering insights into their role in cellular processes such as proliferation, differentiation, and inflammation. BRD inhibitors are widely used in experiments designed to understand how dysregulation of BET proteins contributes to various diseases, including cancer, cardiovascular diseases, and inflammatory disorders. These inhibitors are also instrumental in research focused on developing new strategies that target aberrant gene expression profiles, particularly in diseases where BRD proteins are implicated in the maintenance of pathological states. Additionally, BRD inhibitors are valuable tools for studying the broader impacts of epigenetic regulation on cellular function and for identifying potential biomarkers of disease. The availability of a diverse range of BRD inhibitors allows scientists to conduct targeted experiments that advance our understanding of BET protein function and its implications in health and disease. View detailed information on our available BRD Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

I-BET 151 Hydrochloride

1300031-49-5 (non HCl Salt)sc-391115
10 mg
$450.00
2
(0)

I-BET 151 Hydrochloride is a selective inhibitor of bromodomain-containing proteins, showcasing a unique ability to disrupt protein-protein interactions critical for gene regulation. Its structure facilitates specific hydrogen bonding and hydrophobic interactions, enhancing binding affinity. The hydrochloride form improves solubility, promoting effective cellular uptake. Additionally, its kinetic behavior indicates a sustained engagement with target proteins, influencing epigenetic modulation and transcriptional activity.

GSK 525762A

1260907-17-2sc-490339
sc-490339A
sc-490339B
sc-490339C
sc-490339D
5 mg
10 mg
50 mg
100 mg
1 g
$300.00
$540.00
$940.00
$1680.00
$5900.00
(0)

GSK 525762A is a potent bromodomain inhibitor that exhibits remarkable selectivity through its unique binding profile. Its molecular architecture allows for specific π-π stacking and van der Waals interactions, which enhance its affinity for target proteins. The compound's dynamic behavior in solution suggests rapid conformational changes, optimizing its interaction kinetics. Furthermore, its lipophilic characteristics contribute to membrane permeability, facilitating cellular access and engagement with bromodomain targets.