Date published: 2026-1-28

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BRCAA1 Inhibitors

BRCAA1 Inhibitors are a specialized class of chemical compounds that target and regulate the activity of the BRCAA1 (Breast Cancer Associated Antigen 1) gene, which encodes a protein involved in critical cellular functions related to cell cycle regulation, DNA damage response, and cellular stress responses. The BRCAA1 protein is implicated in various cellular processes, particularly those that influence the stability and integrity of the genome. BRCAA1 is known to interact with several key proteins involved in DNA repair mechanisms and chromosomal maintenance. BRCAA1 Inhibitors work by binding to specific domains of the BRCAA1 protein, inhibiting its ability to participate in protein-protein interactions or cellular pathways associated with genomic surveillance and repair mechanisms. This modulation impacts the pathways controlled by BRCAA1, offering a unique approach to studying how cells manage genomic stress and maintain chromosomal stability.

The study of BRCAA1 Inhibitors opens pathways for investigating the intricacies of cell cycle regulation and genomic maintenance, offering a valuable tool for researchers interested in understanding the molecular details of DNA repair and chromosomal dynamics. By inhibiting BRCAA1, researchers can explore the consequences of impaired DNA repair and how cells respond to various forms of genomic instability. The inhibitors also provide insights into how BRCAA1 is integrated into larger signaling networks that govern cellular proliferation, differentiation, and response to external stressors. In laboratory settings, BRCAA1 Inhibitors can serve as molecular probes to dissect the relationships between DNA repair proteins and other cellular machinery involved in maintaining genomic integrity. Such studies have the potential to enhance our understanding of how BRCAA1 contributes to broader cellular functions beyond its role in genomic surveillance, revealing the complex network of molecular interactions at play in maintaining the stability of the genome.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Olaparib

763113-22-0sc-302017
sc-302017A
sc-302017B
250 mg
500 mg
1 g
$210.00
$305.00
$495.00
10
(1)

PARP inhibitor that prevents single-strand DNA repair. Cells with BRCA1 mutations rely on PARP; inhibiting it causes cell death.

Niraparib

1038915-60-4sc-507492
10 mg
$150.00
(0)

PARP inhibitor that acts similarly to Olaparib. In cells with compromised BRCA1 function, PARP inhibition is particularly effective.

Rucaparib

283173-50-2sc-507419
5 mg
$150.00
(0)

Another PARP inhibitor, which causes synthetic lethality in cells with deficient BRCA1.

Veliparib

912444-00-9sc-394457A
sc-394457
sc-394457B
5 mg
10 mg
50 mg
$182.00
$275.00
$726.00
3
(0)

PARP inhibitor that can exploit the vulnerability of BRCA1-mutated cells by preventing DNA repair.

Talazoparib

1207456-01-6sc-507440
10 mg
$795.00
(0)

PARP inhibitor that binds to DNA and traps PARP on DNA, particularly lethal for BRCA1-deficient cells.

Ceralasertib

1352226-88-0sc-507439
10 mg
$573.00
(0)

ATR kinase inhibitor; ATR is essential for DNA damage response, particularly when BRCA1 is dysfunctional.

BKM120

944396-07-0sc-364437
sc-364437A
sc-364437B
sc-364437C
5 mg
10 mg
25 mg
50 mg
$176.00
$235.00
$281.00
$339.00
9
(0)

Inhibits PI3K, which is part of the AKT-mTOR pathway. BRCA1-mutated tumors can be dependent on this pathway.

MK-2206 dihydrochloride

1032350-13-2sc-364537
sc-364537A
5 mg
10 mg
$182.00
$332.00
67
(1)

Inhibits AKT, downstream of PI3K. BRCA1-mutated tumors might show sensitivity to AKT inhibition.

Everolimus

159351-69-6sc-218452
sc-218452A
5 mg
50 mg
$131.00
$651.00
7
(1)

mTOR is part of the PI3K-AKT pathway, and its inhibition can impact cells with BRCA1 dysregulation.

RAD51 Inhibitor B02

1290541-46-6sc-507533
10 mg
$95.00
(0)

RAD51 is involved in homologous recombination repair, like BRCA1. Inhibiting RAD51 can compound the effects of BRCA1 deficiency.