bomapin Activators
Bomapin activators encompass a range of molecules that enhance the activity of bomapin through various biochemical mechanisms. Dibutyryl cAMP, a cell-permeable analog of cAMP, activates cAMP-dependent pathways, leading to the activation of protein kinase A (PKA), which can phosphorylate bomapin, potentially augmenting its serine protease inhibitory activity. Heparin, a glycosaminoglycan, binds to bomapin and induces conformational changes that may facilitate its interaction with target proteases, thereby enhancing bomapin's inhibitory function. Sodium butyrate, a histone deacetylase inhibitor, can upregulate bomapin expression by inducing hyperacetylation of histones, which affects gene expression and, consequently, increases bomapin's role in regulating innate immunity. Similarly, epigallocatechin gallate (EGCG) stabilizes bomapin through its antioxidative action on protein kinases, while paclitaxel supports the proper cellular localization of bomapin, crucial for its protease inhibition.
The second group of bomapin activators includes small molecule inhibitors that indirectly upregulate bomapin activity by modulating cellular signaling pathways or protein stability. U0126, an inhibitor of MEK1/2, may increase bomapin levels as a compensatory cellular response to blocked MAPK/ERK signaling. MG132, a proteasome inhibitor, prevents bomapin degradation, leading to an accumulation within the cell, thus enhancing its inhibitory potential against serine proteases. LY294002 and SP600125, inhibitors of PI3K and JNK respectively, alter signaling pathways that could result in an enhanced functional state of bomapin. SB203580, targeting p38 MAP kinase, could also elevate bomapin activity by modulating the cellular stress response. Additionally, compounds like curcumin and resveratrol modulate inflammatory responses and deacetylation processes, respectively, contributing to the regulatory effects on bomapin activity, without directly interacting with the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that directly activates cAMP-dependent pathways. Increased cAMP levels can lead to the activation of PKA, which is known to phosphorylate serine protease inhibitors (serpins) like bomapin, thereby potentially enhancing its inhibitory activity. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin is a glycosaminoglycan that binds to various serpins and can cause conformational changes. These changes may enhance bomapin's (SERPINB10) ability to inhibit its target proteases by facilitating the interaction between bomapin and the proteases. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can lead to the hyperacetylation of histones, affecting gene expression. The elevated expression of bomapin could enhance its function in inhibiting serine proteases as part of the regulation of innate immunity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a potent antioxidant found in green tea that can modulate signaling pathways by inhibiting certain protein kinases. By inhibiting these kinases, EGCG could indirectly enhance the activity of bomapin by stabilizing the protein and protecting it from oxidative damage. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can indirectly affect the trafficking and localization of cellular proteins. This may enhance the activity of bomapin by promoting its proper localization in cells where it can effectively inhibit target proteases. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to an accumulation of proteins within the cell. This can indirectly enhance the functional activity of bomapin by preventing its degradation, thereby increasing its concentration and inhibitory potential. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can interfere with the AKT signaling pathway. By inhibiting PI3K, LY294002 could lead to an enhancement of bomapin's function by altering the phosphorylation status of proteins that interact with or regulate bomapin. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is involved in regulating apoptosis and inflammation. Inhibition of JNK could result in increased activity of bomapin, as the protein could be involved in controlling protease activity in these processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase that could enhance bomapin function by modulating the cellular stress response, where serpins like bomapin are known to be active. This could lead to an increase in bomapin activity due to the altered state of the cell. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a compound found in turmeric with anti-inflammatory properties. It can modulate the activity of NF-kB and other inflammatory signaling pathways. By affecting these pathways, curcumin could enhance the activity of bomapin by altering the inflammatory response where bomapin is involved. | ||||||