BMAL1 Activators

Common BMAL1 Activators include, but are not limited to Melatonin CAS 73-31-4, Dexamethasone CAS 50-02-2, Resveratrol CAS 501-36-0, Forskolin CAS 66575-29-9 and Lithium CAS 7439-93-2.

BMAL1 (Brain and Muscle ARNT-like 1) activators are compounds or molecules that stimulate the activity or expression of the BMAL1 gene or protein. BMAL1 is a critical component of the molecular clock machinery, which regulates circadian rhythms in various organisms, including humans. Circadian rhythms are the natural, internal processes that govern the sleep-wake cycle, body temperature, hormone release, and other physiological and behavioral patterns over a roughly 24-hour period. The molecular clock is composed of a network of genes and proteins that form feedback loops, and BMAL1 is a core component of the positive arm of this clock.

BMAL1, along with its partner CLOCK (Circadian Locomotor Output Cycles Kaput), promotes the transcription of other clock-related genes, including Period (PER) and Cryptochrome (CRY) genes. This transcriptional activity leads to the production of PER and CRY proteins, which, when they accumulate, eventually inhibit BMAL1-CLOCK-mediated transcription, creating a negative feedback loop that regulates the circadian rhythm. BMAL1 activators may influence the timing and strength of this transcriptional activity, affecting the overall circadian clock function. Understanding how BMAL1 is activated and the consequences of its activation can provide valuable insights into the regulation of circadian rhythms and their impact on various biological processes, such as metabolism, immunity, and sleep.