BIP Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde | 14003-96-4 | sc-319733 | 500 mg | $360.00 | ||
Also called 4μ8C, this compound is a direct inhibitor of BIP by specifically targeting the IRE1 (Inositol-Requiring Enzyme 1) pathway. It inhibits the activation of IRE1, which is involved in endoplasmic reticulum (ER) stress response. By blocking IRE1, 4μ8C indirectly inhibits BIP expression. IRE1 typically induces the expression of BIP during ER stress, and 4μ8C disrupts this signaling pathway, leading to reduced BIP levels. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal is a chemical compound that indirectly inhibits BIP by targeting the eIF2α (Eukaryotic Initiation Factor 2α) signaling pathway. It promotes the dephosphorylation of eIF2α by inhibiting the enzyme responsible for its dephosphorylation, resulting in the attenuation of global protein synthesis. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $100.00 $459.00 $816.00 $4080.00 $7140.00 | 2 | |
Guanabenz is a chemical compound that indirectly inhibits BIP by targeting the PERK (Protein kinase R-like endoplasmic reticulum kinase) pathway. It promotes the dephosphorylation of eIF2α, a downstream effector of PERK. By inhibiting eIF2α phosphorylation, Guanabenz mitigates translational repression during ER stress, indirectly affecting BIP expression. | ||||||
STF 083010 | 307543-71-1 | sc-474562 sc-474562A sc-474562B sc-474562C sc-474562D | 5 mg 10 mg 50 mg 100 mg 200 mg | $127.00 $180.00 $400.00 $700.00 $1212.00 | 3 | |
STF-083010 is a chemical inhibitor that indirectly targets BIP by modulating the IRE1α-XBP1 (X-box binding protein 1) pathway, a key component of the unfolded protein response (UPR). STF-083010 inhibits XBP1 splicing, a process activated by IRE1α during ER stress. By disrupting XBP1 splicing, STF-083010 indirectly inhibits BIP expression, as XBP1 is a transcription factor that regulates BIP levels. | ||||||
VER 155008 | 1134156-31-2 | sc-358808 sc-358808A | 10 mg 50 mg | $199.00 $825.00 | 9 | |
VER-155008 is a chemical compound that indirectly inhibits BIP by targeting the IRE1α-XBP1 pathway. It specifically inhibits the endonuclease activity of IRE1α, preventing the splicing of XBP1 mRNA. As XBP1 regulates BIP expression, inhibition of IRE1α by VER-155008 indirectly modulates BIP levels. This compound offers an indirect mechanism to influence BIP expression by disrupting the IRE1α-XBP1 signaling axis, a key component of the unfolded protein response (UPR) during ER stress. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is a chemotherapeutic agent that indirectly inhibits BIP expression by influencing the general protein folding and ER stress response. 5-FU induces ER stress by disrupting protein homeostasis, leading to the activation of the unfolded protein response (UPR). As BIP is a key player in the UPR, the induction of ER stress by 5-FU indirectly modulates BIP levels. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxyglucose is a chemical compound that indirectly inhibits BIP expression by targeting the PERK pathway and inducing ER stress. It interferes with glycolysis and ATP production, leading to energy depletion and the activation of the unfolded protein response (UPR). As BIP is a downstream target of PERK during ER stress, 2-Deoxyglucose indirectly modulates BIP levels. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a chemical compound that indirectly inhibits BIP by inducing ER stress through disruption of calcium homeostasis. It inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to calcium release from the ER and subsequent ER stress. As BIP is a key player in the unfolded protein response (UPR), Thapsigargin indirectly modulates BIP levels. | ||||||