Biotin Derivatives

Alpha-Biotin-omega-maleinimido poly(ethylene glycol) is a versatile biotin derivative characterized by its maleimide functionality, which enables selective reactions with thiol groups. The 5,000 dalton PEG segment enhances hydrophilicity and steric hindrance, improving stability and reducing non-specific interactions. This compound exhibits unique reactivity profiles, allowing for controlled conjugation and modular assembly in complex biochemical environments, making it suitable for diverse applications in molecular biology.

Alpha-Biotin-omega-carboxysuccinimidyl ester poly(ethyleneglycol) features a carboxysuccinimidyl ester moiety that facilitates efficient coupling with amine-containing biomolecules. The 10,000 dalton PEG chain imparts significant solubility and biocompatibility, while also providing a flexible linker that enhances spatial orientation. This compound exhibits rapid reaction kinetics, promoting effective conjugation in aqueous environments, and minimizes steric hindrance, allowing for precise molecular interactions in various biochemical contexts.

Alpha-Biotin-omega-carboxysuccinimidyl ester poly(ethyleneglycol) is characterized by its unique biotinylation capabilities, enabling strong affinity for streptavidin and other biotin-binding proteins. The 3,000 dalton PEG segment enhances hydrophilicity and reduces nonspecific interactions, promoting stability in diverse conditions. Its reactive carboxysuccinimidyl ester group allows for swift amine conjugation, facilitating targeted modifications while maintaining structural integrity and functional versatility in biochemical applications.

Alpha-Biotin-omega-carboxysuccinimidyl ester poly(ethyleneglycol) features a distinctive structure that combines biotin's high affinity for specific proteins with a flexible PEG backbone. This design enhances solubility and minimizes aggregation, promoting effective interactions in aqueous environments. The carboxysuccinimidyl ester moiety enables rapid and selective coupling to amine-containing molecules, ensuring efficient bioconjugation while preserving the functional properties of both the biotin and PEG components.

(3aS,4aR)-1,3-Dibenzyldihydro-1H-selenolo[3,4-d]imidazole-2,4-(3H,3aH)dione exhibits intriguing properties as a biotin derivative, characterized by its unique selenium-containing framework. This compound facilitates specific molecular interactions through its imidazole core, enhancing reactivity with biomolecules. Its dual benzyl substituents contribute to hydrophobic interactions, potentially influencing binding affinities and reaction kinetics in complex biological systems.

3-(4-(N-Biotinoyl-6-aminocaproyloxy)phenyl)propionic Acid stands out as a biotin derivative due to its distinctive phenylpropionic structure, which enhances solubility and reactivity. The biotinoyl moiety promotes strong interactions with avidin and streptavidin, facilitating specific binding events. Its unique caproyloxy group introduces flexibility, potentially modulating conformational dynamics and influencing the kinetics of molecular recognition in various biochemical pathways.

6-N-Biotinylaminohexanol is a notable biotin derivative characterized by its hexanol backbone, which enhances hydrophilicity and solubility in aqueous environments. The biotinyl group enables robust interactions with biotin-binding proteins, promoting high-affinity complex formation. Its amino functionality allows for versatile coupling reactions, facilitating the development of diverse bioconjugates. This compound's structural features may also influence molecular stability and reactivity in biochemical assays.

N-(2-Aminoethyl)biotinamide hydrochloride is a distinctive biotin derivative featuring an aminoethyl side chain that enhances its reactivity and solubility in polar solvents. This compound exhibits strong affinity for biotin receptors, facilitating specific molecular interactions that can modulate biological pathways. Its unique structure allows for efficient conjugation with various biomolecules, potentially influencing reaction kinetics and stability in biochemical environments.

6-N-Biotinylaminohexyl Hydrogenphosphonate is a specialized biotin derivative characterized by its unique hydrogenphosphonate group, which enhances its reactivity in phosphorylation reactions. This compound demonstrates a remarkable ability to form stable complexes with metal ions, influencing its behavior in catalytic processes. Its extended hexyl chain contributes to increased hydrophobic interactions, potentially affecting solubility and molecular recognition in diverse biochemical contexts.

6-N-Biotinylaminohexyl Isopropyl Hydrogenphosphonate is a distinctive biotin derivative featuring an isopropyl hydrogenphosphonate moiety that facilitates selective phosphorylation. This compound exhibits unique binding affinities, allowing for specific interactions with biomolecules, which can modulate enzymatic activity. The presence of the biotinyl group enhances its ability to engage in avidin-biotin interactions, while the hexyl chain promotes hydrophobic interactions, influencing its stability and reactivity in various biochemical environments.