Date published: 2025-10-19

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Biotin Derivatives

Santa Cruz Biotechnology now offers a broad range of biotin derivatives for use in various applications. Biotin derivatives, which are chemically modified forms of biotin, have become indispensable tools in scientific research due to their strong affinity for streptavidin and avidin proteins. This high-affinity interaction is exploited in a variety of applications, including bioconjugation, labeling, and purification processes. In molecular biology, biotin derivatives are commonly used to label nucleic acids and proteins, facilitating their detection and isolation in experiments such as Western blotting, ELISA, and immunoprecipitation. These derivatives also play a critical role in developing biotin-streptavidin systems for affinity purification, which are essential for purifying proteins, nucleic acids, and other bioconjugates with high specificity and efficiency. In cell biology, biotinylated molecules are used to study cell surface interactions, receptor binding, and signal transduction pathways, providing insights into cellular mechanisms and functions. Environmental scientists utilize biotin derivatives in biosensor technologies to detect and quantify pollutants and other environmental contaminants, contributing to environmental monitoring and protection efforts. Additionally, in nanotechnology and materials science, biotin derivatives are employed to functionalize nanoparticles and other materials, enabling the development of advanced diagnostic tools and smart materials with tailored properties. By offering a diverse selection of biotin derivatives, Santa Cruz Biotechnology supports a wide range of scientific endeavors, enabling researchers to select the appropriate derivative for their specific experimental needs. This extensive range of biotin derivatives facilitates innovation and discovery across multiple scientific disciplines, including chemistry, biology, environmental science, and materials science. View detailed information on our available biotin derivatives by clicking on the product name.

Items 61 to 70 of 118 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Biotinylamidoethyl]-dithiomethylenemalonic Acid Bis(3-aminopropionic Acid)

sc-221364
5 mg
$430.00
(0)

Biotinylamidoethyl-dithiomethylenemalonic Acid Bis(3-aminopropionic Acid) is a distinctive biotin derivative characterized by its dual functional groups that enable robust interactions with various biomolecular targets. The dithiomethylenemalonic acid component enhances its reactivity, allowing for efficient conjugation through thiol-disulfide exchange mechanisms. This compound's unique architecture facilitates specific binding events, promoting enhanced stability and selectivity in biochemical environments.

[Biotinylamidoethyl]-dithiomethylenemalonic Acid Bis(4-aminobutyric Acid)

1322625-02-4sc-221365
5 mg
$300.00
(0)

[Biotinylamidoethyl]-dithiomethylenemalonic Acid Bis(4-aminobutyric Acid) is a notable biotin derivative featuring a complex structure that supports versatile molecular interactions. Its dithiomethylenemalonic acid moiety introduces unique reactivity profiles, enabling selective modifications via nucleophilic attack. This compound exhibits enhanced solubility and stability in aqueous environments, promoting effective integration into various biochemical pathways and facilitating targeted delivery mechanisms.

2-[(2-Biotinylamidoethyl)dithiopropionylamino]-N-11-[4-benzoyl-1,3-bis-(1,6-anhydro-2,3-isopropylidine-β-D-manopyrano-4-yloxy)-2-propylamino-3,6,9,12

sc-223311
1 mg
$330.00
(0)

2-[(2-Biotinylamidoethyl)dithiopropionylamino]-N-11-[4-benzoyl-1,3-bis-(1,6-anhydro-2,3-isopropylidine-β-D-manopyrano-4-yloxy)-2-propylamino-3,6,9,12 is a sophisticated biotin derivative characterized by its intricate molecular architecture. The presence of dithiopropionylamino groups enhances its reactivity, allowing for specific conjugation with biomolecules. This compound demonstrates unique binding affinities, promoting selective interactions that can influence cellular uptake and localization, thereby enhancing its functional versatility in biochemical applications.

2-[(2-Biotinylamidoethyl)dithiopropionylamino]-N-11-[4-benzoyl-1,3-bis-(D-manos-4-yloxy)-2-propylamino-3,6,9,12-tetraoxododecanyl]-N′-(2-hydroxylcarbonylethylamino)malonic Acid Diamide

sc-223312
1 mg
$360.00
(0)

2-[(2-Biotinylamidoethyl)dithiopropionylamino]-N-11-[4-benzoyl-1,3-bis-(D-manos-4-yloxy)-2-propylamino-3,6,9,12-tetraoxododecanyl]-N′-(2-hydroxylcarbonylethylamino)malonic Acid Diamide is a complex biotin derivative featuring multiple functional groups that facilitate diverse molecular interactions. Its unique dithiopropionylamino moiety promotes enhanced reactivity, enabling targeted conjugation with various substrates. The compound's structural intricacies allow for specific binding mechanisms, potentially influencing reaction kinetics and enhancing selectivity in biochemical pathways.

2-[N2-(6-Aminocaproyl)-N6-(6-biotinamidocaproyl)-L -lysinylamido] Ethyl Methanethiosulfonate Trifluoroacetic Acid Salt

sc-223338
1 mg
$280.00
(0)

2-[N2-(6-Aminocaproyl)-N6-(6-biotinamidocaproyl)-L-lysinylamido] Ethyl Methanethiosulfonate Trifluoroacetic Acid Salt is a sophisticated biotin derivative characterized by its methanethiosulfonate group, which facilitates thiol-specific reactions. This compound exhibits unique reactivity patterns, allowing for selective labeling and conjugation in complex biological systems. Its structural design promotes efficient interactions with biomolecules, potentially influencing binding affinities and enhancing the specificity of biochemical assays.

2-{N2-[Nα-Benzoylbenzoicamido-N6-6-biotinamidocaproyl]lysinylamido}ethyl-2′-carboxylethyl Disulfide

sc-223342
2.5 mg
$360.00
(0)

2-{N2-[Nα-Benzoylbenzoicamido-N6-6-biotinamidocaproyl]lysinylamido}ethyl-2'-carboxylethyl Disulfide is a complex biotin derivative featuring a disulfide linkage that enables redox-sensitive interactions. This compound showcases unique reactivity, allowing for the formation of covalent bonds with thiol-containing biomolecules. Its structural attributes enhance stability and solubility, promoting effective integration into biochemical pathways and facilitating targeted modifications in diverse experimental contexts.

N′-(13-Iodoacetamido-4,7,10-trioxatridecanyl)-N-methyl-N-biotinylglycinamide

sc-224162
1 mg
$380.00
(0)

N'-(13-Iodoacetamido-4,7,10-trioxatridecanyl)-N-methyl-N-biotinylglycinamide is a distinctive biotin derivative characterized by its iodoacetamido group, which facilitates selective labeling of biomolecules through covalent bond formation with nucleophiles. The trioxatridecanyl chain enhances hydrophilicity and molecular flexibility, promoting efficient interactions in aqueous environments. This compound's unique structure allows for specific targeting in biochemical assays, enabling nuanced studies of protein interactions and cellular processes.

2-{N2-[Nα-Benzoylbenzoicamido-N6-6-biotinamidocaproyl]lysinylamido}ethyl-2′-(N-sulfosuccinimidylcarboxy)ethyl Disulfide Sodium Salt

sc-229868
1 mg
$290.00
1
(0)

2-{N2-[Nα-Benzoylbenzoicamido-N6-6-biotinamidocaproyl]lysinylamido}ethyl-2'-(N-sulfosuccinimidylcarboxy)ethyl Disulfide Sodium Salt is a sophisticated biotin derivative featuring a disulfide linkage that enables redox-sensitive applications. Its sulfosuccinimidyl group enhances reactivity with amines, facilitating conjugation to various biomolecules. The compound's unique design promotes stability in diverse environments, allowing for targeted interactions and effective labeling in biochemical studies.

alpha-Biotin-omega-maleinimido poly (ethylene glycol), PEG molecular weight 10,000 daltons

sc-352992
100 mg
$700.00
(0)

Alpha-Biotin-omega-maleinimido poly(ethylene glycol) is a versatile biotin derivative characterized by its maleimide functionality, which enables selective conjugation to thiol-containing molecules. The PEG backbone enhances solubility and biocompatibility, while the 10,000 dalton molecular weight provides optimal steric hindrance for improved interaction dynamics. This compound exhibits unique reaction kinetics, allowing for rapid and efficient labeling in various biochemical contexts, facilitating precise molecular targeting.

alpha-Biotin-omega-maleinimido poly (ethylene glycol), PEG molecular weight 3,000 daltons

sc-352993
100 mg
$700.00
(0)

Alpha-Biotin-omega-maleinimido poly(ethylene glycol) is a specialized biotin derivative featuring a maleimide group that facilitates targeted thiol conjugation. The 3,000 dalton PEG backbone contributes to enhanced solubility and flexibility, promoting effective molecular interactions. Its unique structure allows for rapid reaction kinetics, enabling efficient labeling and stabilization of biomolecules. This compound's distinct properties make it ideal for applications requiring precise molecular recognition and functionalization.