β-defensin 28 Inhibitors

β-Defensin 28 is a member of the defensin family, known for its antimicrobial properties and its role in innate immunity. It is predominantly expressed in epithelial cells, serving as a crucial component of the host defense system by providing protection against a broad spectrum of microorganisms.

The inhibition of β-defensin 28 can be achieved through various mechanisms involving key cellular pathways. The chemicals listed in the table exert their inhibitory effects by targeting specific pathways such as DNA repair (PARP inhibition), PI3K/AKT signaling, JAK-STAT pathway, calcineurin/NFAT, MAPK/ERK, JNK/AP-1, HDAC/chromatin remodeling, Wnt/β-catenin, hypoxia/HIF-1α, TLR4, and mTORC1. These inhibitors disrupt the signaling cascades involved in the transcriptional regulation of β-defensin 28, providing potential avenues for controlling its expression in different physiological contexts. The intricate interplay of these pathways highlights the complexity of β-defensin 28 regulation and presents diverse opportunities for targeted intervention in the context of innate immune responses.