βA3-crystallin Activators
βA3-crystallin Activators encompass a range of chemical compounds that enhance the functionality of βA3-crystallin through various indirect pathways. Retinoic Acid plays a pivotal role in the visual cycle by influencing the RPE65 pathway, thus supporting βA3-crystallin's critical function in visual pigment regeneration. Antioxidants like N-Acetylcysteine and Vitamin E indirectly preserve βA3-crystallin's structural integrity by mitigating oxidative stress, which is vital for maintaining lens clarity and preventing cataract formation. Similarly, Curcumin and Epigallocatechin Gallate (EGCG) exert protective effects on ocular tissues by modulating NF-κB and MAPK pathways, respectively, thereby safeguarding βA3-crystallin function. Resveratrol, through its action on the SIRT1 pathway, and Spermidine, by inducing autophagy, enhance cellular resilience against aging and stress, indirectly benefiting βA3-crystallin's role in the lens.
The influence of flavonoids like Quercetin and Luteolin extends to the PI3K/Akt and GSK-3β pathways, respectively, promoting cell survival and reducing oxidative stress, which is beneficial for βA3-crystallin functionality in the eye. Zinc Sulphate, by enhancing the antioxidant defense system, and Sulforaphane, through activating the Nrf2 pathway, further contribute to the maintenance of lens transparency and protection against cataract formation. Lastly, Taurine's role in modulating calcium signaling and osmoregulation aids in maintaining cellular homeostasis, a condition under which βA3-crystallin performs optimally.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Influences the RPE65 pathway in retinal pigment epithelial cells, enhancing the functional role of βA3-crystallin in visual pigment regeneration. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
As an antioxidant, it modulates oxidative stress pathways, indirectly supporting the structural and functional stability of βA3-crystallin, especially in lens transparency and cataract prevention. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Interferes with NF-κB signaling, reducing stress in ocular tissues, indirectly preserving the function of βA3-crystallin in maintaining lens clarity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid modulating the PI3K/Akt pathway, indirectly preserving βA3-crystallin structure and function under stress conditions, promoting cell survival in ocular tissues. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Plays a role in the antioxidant defense system, indirectly maintaining the functional integrity of βA3-crystallin, particularly in lens oxidative damage prevention. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Influences the SIRT1 pathway, supporting the stability and function of βA3-crystallin by enhancing cellular resilience against oxidative and aging-related stresses in ocular tissues. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Enhances cellular cleanup mechanisms through autophagy induction, indirectly supporting the functionality of βA3-crystallin by reducing protein aggregation in the lens. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol modulating NF-κB and MAPK signaling, supporting βA3-crystallin function by protecting ocular tissues from oxidative stress. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
As an antioxidant, it protects cell membranes from oxidative damage, indirectly benefiting βA3-crystallin by preserving lens structure and function. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Influences the GSK-3β pathway, indirectly supporting βA3-crystallin function by promoting neuronal survival and reducing oxidative stress, beneficial for retinal health. | ||||||