β-1,4-GalNAc-T2 Activators
β-1,4-GalNAc-T2 activators belong to a specific chemical class that plays a crucial role in glycosylation processes within biological systems. These activators are compounds designed to modulate the activity of the enzyme β-1,4-N-acetylgalactosaminyltransferase 2, often abbreviated as β-1,4-GalNAc-T2. This enzyme is a member of the glycosyltransferase family and is responsible for catalyzing the transfer of N-acetylgalactosamine (GalNAc) residues onto specific serine and threonine residues of glycoproteins. These modifications, known as O-glycosylation, are vital for various cellular processes, including cell signaling, cell adhesion, and the stability and function of glycoproteins.
β-1,4-GalNAc-T2 activators function by enhancing the enzymatic activity of β-1,4-GalNAc-T2, thereby increasing the rate at which GalNAc residues are added to target glycoproteins. This chemical class's significance lies in its ability to influence glycosylation patterns, which can have far-reaching effects on cellular functions. By fine-tuning O-glycosylation, researchers aim to better understand the role of glycoproteins in various physiological and pathological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine disodium salt | 108320-87-2 | sc-286850 sc-286850A sc-286850B sc-286850C | 1 mg 2 mg 25 mg 100 mg | $124.00 $292.00 $1326.00 $3876.00 | ||
UDP-GalNAc serves as a donor substrate for β-1,4-GalNAc-T2, facilitating its glycosyltransferase activity. The availability of this sugar nucleotide directly enhances the enzyme's functional role in the biosynthesis of glycolipids and glycoproteins. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese ions are essential cofactors for β-1,4-GalNAc-T2, as they are required for the proper folding and catalytic function of the enzyme. Supplementing with MnCl2 can enhance the activity of β-1,4-GalNAc-T2 by ensuring the availability of these necessary ions. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions are involved in the regulation of many enzymatic activities within the Golgi apparatus. β-1,4-GalNAc-T2, being a Golgi-resident enzyme, may require optimal levels of calcium for its maximal activity. The addition of CaCl2 can provide these ions, indirectly enhancing the protein's function. | ||||||
Phosphatidyl-L-serine | 51446-62-9 | sc-507548 | 10 g | $46.00 | ||
Phosphatidylserine is a phospholipid that is a component of the Golgi membrane. The presence of phosphatidylserine can influence the membrane environment, potentially enhancing the activity of membrane-associated enzymes like β-1,4-GalNAc-T2. | ||||||
Sphingomyelin | 85187-10-6 | sc-201381 sc-201381A | 100 mg 500 mg | $180.00 $560.00 | 3 | |
Sphingomyelin is a component of the Golgi membrane and can influence the membrane environment and raft domains, where β-1,4-GalNAc-T2 may be active. Modifying the membrane composition with sphingomyelin could enhance the enzyme's activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a coenzyme in many enzymatic reactions and is involved in the maintenance of cellular redox state. While not directly involved in β-1,4-GalNAc-T2's catalytic activity, optimal levels of NAD+ can support the overall cellular environment conducive to its activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can activate PKA. PKA phosphorylates various proteins, potentially including those involved in glycosylation processes or Golgi function, thereby indirectly enhancing the activity of β-1,4-GalNAc-T2. | ||||||