BC061194 Inhibitors

BC061194, a protein intricately involved in cell cycle progression and mitotic control, has garnered attention for research. Understanding its inhibition through specific inhibitors sheds light on the regulatory mechanisms governing cellular processes. BC061194 is closely associated with the Polo-like kinase (PLK) family, particularly PLK1 and PLK4, which play crucial roles in mitosis, centrosome maturation, and cell cycle regulation. Inhibition of PLK1 by BI-2536, GSK461364, ON-01910, SBE13, Poloxin, GSK461364X, BI6727, and TAK-960 underscores the significance of targeting PLK1 to influence BC061194 expression and function. These inhibitors disrupt the intricate orchestration of mitotic events, providing insights into the dynamic regulation of cell division.

Additionally, BC061194 inhibition is extended to PLK4 through Centrinone and CFI-400945, highlighting the protein's involvement in centrosome maturation and cell cycle progression. HMN-214, an Aurora A kinase inhibitor, introduces an additional layer of complexity, influencing BC061194 indirectly by targeting Aurora A kinase, a key player in mitotic progression and centrosome maturation. In summary, BC061194 inhibitors provide valuable tools for unraveling the intricate molecular pathways governing cell cycle progression and mitotic control.