BAT4 Inhibitors
BAT4 inhibitors are a class of chemical compounds that target the BAT4 (HLA-B associated transcript 4) protein, a protein encoded by the BAT4 gene, located within the major histocompatibility complex (MHC) region on chromosome 6. Though its exact function is not entirely understood, BAT4 is believed to play a role in immune system regulation and possibly in the modulation of gene expression within the MHC region. BAT4 inhibitors would work by disrupting the normal activity of this protein, potentially affecting the pathways in which it is involved, such as interactions with other proteins within the immune response or gene regulation systems. This inhibition would provide valuable insights into the functional role of BAT4 within cellular processes, especially those related to immune system activity.
BAT4 inhibitors are designed as small molecules, peptides, or nucleic acid-based compounds that interact with specific domains or regions of the BAT4 protein, affecting its structure or its ability to bind with other molecules. These inhibitors could block the protein's active or binding sites, thereby preventing it from fulfilling its biological role. The development of BAT4 inhibitors would likely rely on molecular techniques such as X-ray crystallography or molecular docking studies to identify key interaction points and structural motifs on the BAT4 protein. Further, high-throughput screening of chemical libraries and structure-activity relationship (SAR) studies would assist in refining these inhibitors for increased specificity and efficacy. Research into BAT4 inhibitors could shed light on the broader regulatory mechanisms within the MHC region and enhance understanding of protein interactions that occur in immune system regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine could theoretically lead to hypomethylation of the BAT4 gene promoter, which might inadvertently reactivate genes. However, if BAT4 expression is normally upregulated by methylation, this could paradoxically decrease its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
By inhibiting histone deacetylases, Trichostatin A causes an accumulation of acetylated histones. If BAT4 is normally silenced by histone deacetylation, the hyperacetylated state could indirectly downregulate its expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
This histone deacetylase inhibitor might lead to changes in chromatin structure surrounding the BAT4 gene, potentially resulting in a decrease in BAT4 transcription if it is normally activated by deacetylation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG 108 could lead to the demethylation of the BAT4 promoter region, potentially reducing its expression if methylation is essential for its activation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
As a cytidine analog, 5-Aza-2′-Deoxycytidine incorporates into DNA and inhibits methylation. If the BAT4 gene is normally kept active by methylation, then the hypomethylation could result in a reduction in BAT4 levels. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram could inhibit the proteasome, leading to the accumulation of transcriptional repressors that might downregulate BAT4 gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
This molecule can bind to retinoic acid receptors, altering the transcription of target genes. It might downregulate BAT4 by promoting the expression of transcriptional repressors or by antagonizing activators of BAT4. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been observed to downregulate the expression of various genes by inhibiting the activation of transcription factors such as NF-κB. It could theoretically reduce BAT4 expression by a similar mechanism. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
This compound can inhibit histone deacetylase, potentially leading to the downregulation of BAT4 expression if the gene is normally activated by histone deacetylation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As an isoflavone that can function as an estrogen receptor modulator, Genistein might downregulate BAT4 expression by binding to estrogen receptors that suppress the transcription of the gene. | ||||||