BARD1 Activators
BARD1 activators belong to a specialized class of chemical compounds designed to modulate the activity of the BRCA1-associated RING domain protein 1 (BARD1). BARD1 is a key protein involved in various cellular processes, particularly those related to DNA repair and maintenance of genomic stability. It forms a functional complex with the breast cancer susceptibility gene 1 (BRCA1) protein, and together, they play critical roles in the repair of DNA damage, regulation of cell cycle checkpoints, and the maintenance of genomic integrity. BARD1 contains a RING domain, which is essential for its role as an E3 ubiquitin ligase, facilitating the ubiquitination of target proteins involved in DNA repair pathways.
BARD1 activators are designed to interact with the BARD1 protein, modulating its enzymatic activity and functions within the cell. These compounds are invaluable tools for researchers investigating the intricate molecular mechanisms underlying DNA repair, genome stability, and cellular responses to DNA damage. By manipulating BARD1 activity, scientists can gain insights into the complex processes that safeguard the integrity of the genome and prevent the accumulation of mutations, which are often associated with various genetic disorders, including cancer. BARD1 activators play a pivotal role in advancing our understanding of the fundamental biology of DNA repair pathways and their significance in maintaining genomic stability, contributing to the broader field of molecular and cellular biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may enhance BARD1 expression by acting as an antioxidant and modulating signaling pathways associated with cellular stress and DNA repair. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to influence multiple cellular processes, including DNA repair mechanisms, potentially upregulating BARD1 expression as part of the cellular response to DNA damage. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, a compound in cruciferous vegetables, may induce BARD1 expression through its role in detoxification pathways and oxidative stress response. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen may affect BARD1 expression through its estrogen receptor modulating activity and impact on DNA repair processes. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase inhibitor, can increase BARD1 expression as part of the cellular response to DNA strand breaks. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine may modulate BARD1 expression through its effects on cell cycle checkpoints and DNA damage response. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of vitamin B3, can influence BARD1 expression potentially through pathways involving DNA repair and cellular stress response. | ||||||