Bag-2 Activators
The class of BAG-2 activators encompasses a diverse group of chemicals that indirectly influence the activity of BAG-2, primarily through modulating stress response pathways, protein folding, and degradation mechanisms. Given the role of BAG-2 in interacting with HSP70/HSC70 chaperones, compounds that affect these chaperones or related proteins can indirectly modulate BAG-2 function. For instance, HSP90 inhibitors like Geldanamycin and its derivative 17-AAG could impact BAG-2 indirectly by altering the HSP70/HSC70 activity. Additionally, compounds that induce cellular stress, such as Tunicamycin and Thapsigargin, might also modulate BAG-2 activity, given its involvement in stress responses.
Moreover, the influence of other signaling molecules like p53 (modulated by Pifithrin-μ) and pathways influenced by natural compounds (e.g., Quercetin, Curcumin, Resveratrol, and EGCG) offers potential indirect mechanisms to modulate BAG-2. The proteasome inhibitor MG-132 and Salubrinal, which targets eIF2α phosphorylation, represent other classes of compounds that could indirectly affect BAG-2 through their roles in protein degradation and stress response. It's important to note that these compounds do not activate BAG-2 directly but may influence its activity within the complex network of cellular signaling and stress response pathways. As such, they represent potential tools for studying BAG-2 function and its role in various biological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pifithrin-μ | 64984-31-2 | sc-203195 sc-203195A | 10 mg 50 mg | $127.00 $372.00 | 4 | |
Pifithrin-μ inhibits p53, a protein that can interact with BAG-2. Modulating p53 activity may indirectly influence BAG-2. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can lead to increased stress response, potentially affecting BAG-2 activity through its role in protein folding and degradation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin affects multiple signaling pathways, including those related to stress response, which may indirectly influence BAG-2 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Known to affect sirtuin pathways and stress response, which could indirectly modulate BAG-2 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A green tea polyphenol that influences numerous signaling pathways, possibly affecting BAG-2 indirectly. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Targets eIF2α phosphorylation, affecting stress response pathways that could indirectly modulate BAG-2. | ||||||
6-Hydroxydopamine hydrochloride | 28094-15-7 | sc-203482 | 100 mg | $146.00 | 8 | |
A neurotoxin that induces oxidative stress, potentially affecting BAG-2 activity through stress response pathways. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Induces ER stress, which can influence BAG-2 activity indirectly due to its role in stress response. | ||||||