BAF170 Inhibitors
BAF170 Inhibitors constitute a class of chemical compounds that possess the capability to directly or indirectly inhibit the function of BAF170, a crucial component of the SWI/SNF chromatin remodeling complex. These inhibitors play a significant role in modulating chromatin structure and gene expression by targeting BAF170's bromodomain or influencing downstream signaling pathways. Direct inhibitors such as I-BET151, JQ1, PFI-3, A-485, CPI-637, OTX-015, I-CBP112, GSK2801, EP300 Inhibitor C646, and BETd-246 exert their inhibitory effects by specifically targeting the bromodomain of BAF170. This disruption of the interaction between BAF170 and acetylated histones leads to the inhibition of chromatin remodeling processes and gene expression regulation. These direct inhibitors serve as valuable tools in understanding the functional roles of BAF170 in epigenetic regulation.
In addition to direct inhibitors, there are indirect inhibitors like N-Methylbenzamide (NMA), which do not directly bind to BAF170 but instead influence downstream signaling pathways. NMA can modulate pathways associated with chromatin remodeling, ultimately leading to the inhibition of BAF170's activity. This indirect inhibition highlights the intricate network of regulatory mechanisms governing BAF170 function. In summary, BAF170 Inhibitors represent a diverse group of chemicals that can either directly target the bromodomain of BAF170 or influence downstream pathways involved in chromatin remodeling. These inhibitors provide valuable insights into the regulatory mechanisms governing BAF170's role in epigenetic regulation and gene expression control.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a direct inhibitor of BAF170. It functions by targeting the bromodomain, preventing BAF170 from interacting with acetylated histones and thereby inhibiting chromatin remodeling processes. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is another direct inhibitor of BAF170, targeting its bromodomain. It disrupts the interaction between BAF170 and acetylated histones, inhibiting chromatin remodeling and gene regulation activities. | ||||||
PFI 3 | 1819363-80-8 | sc-507340 | 10 mg | $300.00 | ||
PFI-3 is a direct inhibitor of BAF170 that specifically targets its bromodomain. By disrupting the interaction between BAF170 and acetylated histones, PFI-3 inhibits chromatin remodeling and gene expression regulation. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A-485 is a direct inhibitor of BAF170 and other bromodomain-containing proteins. It interferes with the binding of BAF170 to acetylated histones, leading to the inhibition of chromatin remodeling and gene regulation processes. | ||||||
(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide | 202590-98-5 | sc-501130 | 2.5 mg | $330.00 | ||
This compound, also called OTX-015, is a direct inhibitor of BAF170, acting on its bromodomain. By disrupting the interaction between BAF170 and acetylated histones, it inhibits chromatin remodeling and gene regulation activities. | ||||||
I-CBP112 | 1640282-31-0 | sc-507494 | 25 mg | $400.00 | ||
I-CBP112 is a direct inhibitor of BAF170 that specifically targets its bromodomain. It interferes with the interaction between BAF170 and acetylated histones, leading to the inhibition of chromatin remodeling and gene expression regulation. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
EP300 Inhibitor C646 is a direct inhibitor of BAF170. It acts by blocking the interaction between BAF170 and the EP300 protein, inhibiting histone acetylation and chromatin remodeling processes. | ||||||
BETd-246 | 2140289-17-2 | sc-507288 | 5 mg | $1071.00 | ||
BETd-246 is a direct inhibitor of BAF170 that targets its bromodomain. It disrupts the binding of BAF170 to acetylated histones, leading to the inhibition of chromatin remodeling and gene expression regulation. | ||||||
N-Methylbenzamide | 613-93-4 | sc-236065 | 5 g | $53.00 | ||
N-Methylbenzamide (NMA) is a chemical that indirectly inhibits BAF170 by influencing the downstream signaling pathways. It can modulate pathways involved in chromatin remodeling, indirectly impacting BAF170's activity. | ||||||