AUP1 Activators

AUP1 Activators encompass a diverse range of chemicals known to influence endoplasmic reticulum-associated protein degradation (ERAD) and lipid droplet (LD) formation, the processes in which AUP1 plays a pivotal role. At the forefront are chemicals like Thapsigargin and Tunicamycin. Thapsigargin serves as an ER stress inducer, elevating the ERAD processes, which in turn can impact AUP1's dedicated role in this pathway. On the other hand, Tunicamycin induces the unfolded protein response (UPR), indirectly affecting ERAD and influencing AUP1.

Proteasome inhibitors, such as MG132, can affect AUP1's function in protein degradation. The influence of Brefeldin A on ER-to-Golgi transport underscores its ability to affect ER functions, which in turn can affect AUP1's activity. Chemicals that modulate lipid processing, like Forskolin, which increases cAMP levels, can impact AUP1's function in lipid droplet formation. In the realm of fatty acids, both Oleic Acid and Palmitic Acid have been shown to modulate lipid droplet formation, thereby influencing AUP1. Rosiglitazone, a PPARγ agonist, affects lipid metabolism, offering another route of influence on AUP1's function concerning lipid droplets. Fenretinide's role in lipid metabolism can also influence AUP1's dedicated function. The mTOR inhibitor, Torin 1, affects cellular lipid metabolism, suggesting another potential avenue of influence on AUP1. Lastly, DBeQ, an ATP-competitive p97 inhibitor, and Eeyarestatin I, an ERAD inhibitor, emphasize the diverse methods through which chemicals can affect the ERAD pathway, hence AUP1's function within it.