ATP10C Activators
ATP10C Activators are a diverse group of chemical compounds that, while not directly interacting with ATP10C, create cellular conditions that indirectly stimulate its activity. ATP10C, a phospholipid flippase, is critical in maintaining the asymmetric distribution of lipids across the plasma membrane, an essential factor for various cellular processes including signaling, vesicle formation, and cell recognition. The activators identified work primarily by disrupting the homeostasis of ions within the cell, which in turn, can compel the cell to engage compensatory mechanisms that involve ATP10C function. For example, compounds such as ouabain and digoxin inhibit the Na⁺/K⁺-ATPase pump, causing intracellular sodium to rise, leading to a compensatory increase in the activity of ATP10C as it works to restore the proper distribution of lipids in the cell membrane. Other activators, such as ionophores and calcium channel blockers, function by altering the concentrations of key ions like calcium, sodium, and potassium within the cell, triggering a cascade of intracellular responses. These responses often include the upregulation of ATP10C's lipid translocation activity, as the cell attempts to maintain membrane integrity and signaling functions in the face of ionic disturbances. Thus, although ATP10C activators may not bind directly to the flippase, their influence on the cellular ionic environment plays a pivotal role in modulating the enzyme's activity, and by extension, the overall lipid landscape of the cell membrane.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain is a known inhibitor of the Na⁺/K⁺-ATPase pump, leading to an increase in intracellular sodium levels. This increase can indirectly enhance the function of ATP10C by creating a gradient that favors the activation of secondary transport mechanisms, which may work in concert with ATP10C to maintain ionic homeostasis and phospholipid translocation. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin is another Na⁺/K⁺-ATPase inhibitor that increases intracellular sodium concentrations. Enhanced sodium gradients can facilitate the functional activity of ATP10C by indirectly promoting the exchange of ions and lipids across the cell membrane, a process where ATP10C is directly involved. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a sodium ionophore that disrupts sodium homeostasis by allowing Na⁺ ions to flow down their concentration gradient into the cell. This perturbation of the sodium gradient can lead to compensatory cellular responses that indirectly enhance ATP10C activity as the cell works to restore ionic balance and membrane phospholipid composition. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $46.00 $112.00 $240.00 $7079.00 $27417.00 | 9 | |
Nigericin is a potassium ionophore that exchanges intracellular H⁺ for extracellular K⁺, affecting the intracellular pH and potassium balance. These changes can activate cellular mechanisms to maintain pH and ionic balance, potentially enhancing the activity of ATP10C in lipid translocation in an indirect manner. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone has been shown to stimulate the activity of certain phospholipid flippases. It may enhance the activity of ATP10C by modulating the lipid environment in which ATP10C operates, thereby facilitating its lipid flipping activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations, potentially enhancing ATP10C activity by stimulating calcium-dependent signaling pathways that interact with phospholipid transport processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels. The resulting activation of calcium-dependent signaling pathways can indirectly enhance the activity of ATP10C, as these pathways are often involved in the regulation of membrane lipid dynamics and homeostasis. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that alters intracellular calcium dynamics. By modulating calcium signaling, verapamil can indirectly enhance ATP10C activity, potentially affecting its role in maintaining the asymmetric distribution of phospholipids in the cell membrane. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $38.00 $1155.00 $122.00 | 3 | |
4-Aminopyridine is a potassium channel blocker that can elevate intracellular potassium levels, potentially altering cellular ionic balance. This imbalance may indirectly enhance ATP10C activity as the cell activates mechanisms to restore ion homeostasis, which could involve ATP10C-mediated phospholipid translocation. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Valinomycin is a potassium ionophore that specifically transports K⁺ ions across cellular membranes. This transport can disturb the ion equilibrium and potentially enhance ATP10C activity indirectly through compensatory cellular processes that restore ion gradients, involving ATP10C in phospholipid flipping. | ||||||