Atg14 Inhibitors

Chemical Class Description: The class of Atg14 inhibitors includes a diverse array of compounds that indirectly modulate the activity of Atg14 by targeting various components of the autophagy pathway and related cellular processes. These compounds do not directly interact with Atg14 but influence the cellular environment and mechanisms crucial for Atg14's role in autophagosome formation and autophagy initiation. For instance, 3-Methyladenine and LY294002 inhibit class III PI3K, a key kinase in the autophagy pathway where Atg14 is active. Wortmannin, as a broad PI3K inhibitor, potentially impacts signaling processes crucial for Atg14's function in autophagy.

Chloroquine and Hydroxychloroquine, by preventing autophagosome-lysosome fusion, and Bafilomycin A1, inhibiting vacuolar-type H+-ATPase, disrupt crucial steps in the autophagy pathway, thereby indirectly affecting Atg14's function. mTOR inhibitors like Rapamycin and Torin 1, while inducing autophagy, can also modulate Atg14-dependent processes. Spautin-1, promoting autophagy degradation, and Vinblastine, disrupting microtubules, represent different mechanisms of indirectly influencing Atg14's role in autophagosome transport and formation. Resveratrol, by modulating autophagy, and SB203580, as a p38 MAPK inhibitor, further illustrate the diverse ways in which Atg14's involvement in autophagy can be modulated.