ASZ1 Inhibitors
ASZ1 inhibitors are a class of chemical compounds that function by targeting and modulating the activity of the ASZ1 protein, a member of the PIWI protein family. The ASZ1 protein is involved in the regulation of gene expression, particularly within the context of small RNA pathways, such as piRNA (PIWI-interacting RNA). These pathways play a crucial role in maintaining genomic integrity by silencing transposable elements and regulating the expression of genes, particularly during germ cell development. ASZ1, by interacting with piRNAs and other molecular partners, contributes to RNA-based mechanisms that modulate epigenetic regulation and transposon control.
Inhibitors of ASZ1 are designed to block or reduce the protein's activity, which in turn impacts the downstream pathways that rely on ASZ1 function. These inhibitors may act by directly binding to the protein's active site, interfering with its ability to bind RNA molecules or other cofactors, or by disrupting the protein's structural conformation, leading to its inactivation. The development of ASZ1 inhibitors often involves detailed biochemical studies to understand the structure-function relationships of the protein, as well as the design of small molecules that can effectively modulate its activity. Researchers employ a variety of chemical and biological techniques, such as high-throughput screening, molecular docking, and crystallography, to identify and refine potent inhibitors that specifically target ASZ1 while minimizing off-target effects.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine could cause hypomethylation of the ASZ1 gene promoter, leading to the recruitment of transcriptional repressors that decrease ASZ1 transcription. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram may indirectly reduce ASZ1 expression by disrupting cellular copper homeostasis, which is essential for the function of certain transcription factors that drive ASZ1 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
By inhibiting tyrosine kinases, Genistein could disrupt signal transduction pathways that lead to the activation of ASZ1 gene transcription. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib might downregulate ASZ1 expression by stabilizing negative transcriptional regulators of the ASZ1 gene, which are normally degraded by the proteasome. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might decrease ASZ1 expression by enhancing SIRT1 activity, which could lead to deacetylation of histones at the ASZ1 promoter and tighter chromatin conformation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may inhibit HDACs, leading to hyperacetylation of histones around the ASZ1 gene and subsequent recruitment of transcriptional repressors that decrease ASZ1 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could downregulate ASZ1 expression by inhibiting NF-κB signaling, which might be necessary for the transcriptional activation of the ASZ1 gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin may decrease ASZ1 expression by inhibiting mTOR signaling, which is involved in the regulation of cell growth and could be crucial for the transcriptional activation of ASZ1. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone might reduce ASZ1 expression by antagonizing aldosterone, which could disrupt mineralocorticoid receptor-mediated transcriptional activation of the ASZ1 gene. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol could inhibit cyclin-dependent kinases, leading to cell cycle arrest and a subsequent reduction in ASZ1 expression as part of a broader alteration in gene expression associated with cell cycle progression. | ||||||