ASXL2 Activators
The ASXL2 Activators are a group of chemical compounds specifically selected for their potential to enhance the functional activity of ASXL2, which is intricately involved in chromatin remodeling and the regulation of gene expression. DNA methyltransferase inhibitors like 5-Aza-2'-deoxycytidine and RG108 are pivotal as they may amplify ASXL2's influence on epigenetic mechanisms governing gene expression. Similarly, histone deacetylase inhibitors such as Trichostatin A, Vorinostat, MS-275, and Panobinostat are crucial for potentially augmenting ASXL2's role in histone modification and chromatin restructuring, thereby influencing transcriptional regulation.
Compounds targeting specific histone methyltransferases like GSK126 (EZH2 inhibitor), BIX-01294, and UNC1999, provide a strategic approach to modulate interactions between ASXL2 and components of the polycomb repressive complex 2, crucial in histone methylation and gene silencing. The inclusion of JQ1, a BET bromodomain inhibitor, along with the Menin-MLL inhibitor, underlines the importance of ASXL2 in broader chromatin organization and gene expression processes. EPZ-6438, a selective EZH2 inhibitor, further emphasizes the role of ASXL2 in the context of chromatin dynamics and epigenetic regulation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor, may enhance ASXL2's role in epigenetic regulation of gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor, could augment ASXL2's function in histone modification and chromatin remodeling. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another histone deacetylase inhibitor, may influence ASXL2's activity in transcription regulation. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $90.00 $238.00 $300.00 | ||
Targets the EZH2 methyltransferase, potentially affecting ASXL2's interaction with polycomb repressive complex 2. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
Inhibits G9a histone methyltransferase, might enhance ASXL2's regulatory role in histone methylation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
A BET bromodomain inhibitor, could impact ASXL2's function in chromatin organization and gene expression. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
An EZH1/EZH2 inhibitor, may influence ASXL2's involvement in histone methylation and gene regulation. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
A selective EZH2 inhibitor, could modulate ASXL2's activity in chromatin remodeling. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
A DNA methyltransferase inhibitor, potentially enhancing ASXL2's role in DNA methylation and gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
A selective HDAC inhibitor, might augment ASXL2's function in histone acetylation and transcriptional regulation. | ||||||