ASL Activators
ASL Activators are a class of chemicals that can indirectly influence the activity of argininosuccinate lyase, a crucial enzyme in the urea cycle. This cycle is vital for the detoxification of ammonia and the production of urea in the liver. The proposed activators include a variety of compounds, ranging from substrates and products of the urea cycle to essential cofactors and metabolites from related pathways.
Firstly, substrates and intermediates of the urea cycle like arginine, citrulline, and aspartic acid play a significant role in the regulation of ASL. An increase in the levels of these substances can enhance the demand for ASL activity, thereby potentially increasing its activity. Similarly, the byproduct ornithine might indicate a feedback mechanism influencing ASL. N-Acetylglutamate, as a cofactor for carbamoyl phosphate synthetase I, indirectly affects the urea cycle's flux, which can lead to an increased requirement for ASL activity. Additionally, the involvement of other metabolic intermediates and cofactors underscores the interconnected nature of metabolic pathways. Compounds like alpha-ketoglutarate, fumarate, and malate, integral to the tricarboxylic acid cycle, can impact the supply of intermediates for the urea cycle. This impact, in turn, may alter ASL activity. Zinc and magnesium, as essential cofactors for numerous enzymes, are hypothesized to influence the structural and functional integrity of ASL. Lastly, nitric oxide donors represent a unique category, as nitric oxide can modulate various metabolic processes, including those in the urea cycle, thereby indirectly influencing ASL activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
As a substrate in the urea cycle, an increase in arginine levels can stimulate the cycle, thereby indirectly increasing ASL activity. | ||||||
N-Acetyl-L-glutamic acid | 1188-37-0 | sc-228659 | 25 g | $72.00 | ||
It is an essential cofactor for carbamoyl phosphate synthetase I (CPS1) in the urea cycle. Enhancing CPS1 activity can indirectly increase the demand for ASL activity. | ||||||
L-Citrulline | 372-75-8 | sc-204784 sc-204784A | 25 g 200 g | $32.00 $240.00 | ||
As a part of the urea cycle, increased citrulline can lead to a higher demand for ASL activity to maintain cycle efficacy. | ||||||
Ornithine | 70-26-8 | sc-507552 | 100 mg | $77.00 | ||
As a byproduct of the reaction catalyzed by ASL, an increase in ornithine can suggest a feedback mechanism that may enhance ASL activity. | ||||||
L-Aspartic acid | 56-84-8 | sc-472377A sc-472377 sc-472377B | 25 g 100 g 500 g | $40.00 $33.00 $48.00 | ||
Being part of the aspartate-argininosuccinate shunt, it can influence the balance of substrates and products in the urea cycle, potentially affecting ASL activity. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $43.00 $57.00 $114.00 $228.00 | ||
As part of the tricarboxylic acid cycle, it might have a role in modulating the flux of metabolites in the urea cycle, affecting ASL activity. | ||||||
Malic acid | 6915-15-7 | sc-257687 | 100 g | $130.00 | 2 | |
Involved in the tricarboxylic acid and urea cycles, malate can influence the balance of intermediates, potentially affecting ASL activity. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
As a key amino acid in nitrogen metabolism, glutamate's levels can influence the urea cycle and thereby ASL activity. | ||||||